When these drugs are metabolized, they liberate para-aminobenzoicacid (PABA). As a parent molecule to methylparaben, PABA may be the culprit of the hypersensitivity reaction; however, it is inappropriate to assume cross-reactivity with sulfonamide antibiotics and methylparaben or other para-substituted...
In RNA, the sugar is ribose, and uracil replaces thymine as one of the nitrogenous bases. The metabolism of adenine and guanine (nitrogenous bases in the DNA) occurs stepwise. Adenine is converted to hypoxanthine and guanine to xanthine, metabolized into uric acid by the enzyme xanthine ...
This suggests that histamine released from MCs may be initially metabolized by HNMT from other cells, and the derivate subsequently transported to MCs for further breakdown by MAO-B. In summary, the high expression of MAOs in MCs is intriguing and the enzymes could perform important functions in...