Structure–activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity. Biochem. Biophys. Res. Commun. 116, 492–499 (1983). Article CAS PubMed Google Scholar Hirsh, J. et al. Heparin and low-molecular-weight...
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children and elderly people. Although the virus was isolated in 1955, an effective RSV vaccine has not been developed, and the only licensed intervention is
Plasma is the liquid portion of the blood. Blood cells like red blood cells float in the plasma. Also dissolved in plasma are electrolytes, nutrients and vitamins (absorbed from the intestines or produced by the body), hormones, clotting factors, and proteins such as albumin and immunoglobulins...
A conserved lysine and/or a Mg2+ also may be involved in activating the water and stabilizing the pentavalent transition state produced at the scissile phosphorous (10). Inversion occurs as the 3´-OH leaving group is protonated by a Mg2+-bound water upon exit. Regardless of the mechanism ...
Plasma is the liquid portion of the blood. Blood cells like red blood cells float in the plasma. Also dissolved in plasma are electrolytes, nutrients and vitamins (absorbed from the intestines or produced by the body), hormones, clotting factors, and proteins such as albumin and immunoglobulins...
In healthy conditions and the absence of blood vessel injury, the tendency to form venous and arterial clots is kept in check by molecules that inhibit activation of the clotting cascade and promote fibrinolysis. These include tissue factor pathway inhibitor, antithrombin, heparin, and proteins C an...
Plasma is the liquid portion of the blood. Blood cells like red blood cells float in the plasma. Also dissolved in plasma are electrolytes, nutrients and vitamins (absorbed from the intestines or produced by the body), hormones, clotting factors, and proteins such as albumin and immunoglobulins...
Obesity is associated with a chronic inflammatory state that can affect the hypothalamic–pituitary–gonadal (HPG) axis through the production of cytokines. TNF-α and interleukin (IL)-1β could reduce T production by Leydig cells68. IL-6, produced in large quantities during inflammation, could ...
4) Vaccines that have not been produced properly and undergone adequate quality control may contain virulent organisms which could produce severe disease (this is very rare). 5) Some live vaccines, if given by the wrong route, can cause severe illness (e.g. injectable cat flu vaccine viruses...
is primarily derived from animals, like pigs and cows, because it is naturally synthesized in the mast cells of these creatures – produced as part of their natural defense mechanism against injury or infection. The complex structure of heparin als...