A mutant allele assay or wild type allele assay is composed of an allele-specific primer (red), locus-specific primer (purple), locus-specific TaqMan probe (green), and allele-specific blocker (blue). The level of mutation present in the sample is calculated ...
collection correspond to either the mutant allele described previously for the r locus or a mutation at a second genetic locus, rb, affecting the gene encoding the large subunit of Adenosine diphosphoglucose (ADP-glucose) pyrophosphorylase; th...
It is doubtful this bias can be fully ascribed to standard ascertainment bias (that is bias for markers which are more polymorphic than average in the sample used for marker discovery). We suspect these loci have been further selected for their high difference in allele frequencies between ...
RECOMBINANT‐INBRED STRAINS AN AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES The development of sevenrecombinant-inbred(RI) strains is described. The results of allele typing the seven strains at eight histocompatibility (H) loci ar......
This is valid if the cells behave as a single population, but masks the potential effects of the specific subpopulations. To determine whether there are subpopulations with different behavior, we tested whether the shapes of these distributions were well described by a theoretical distribution (...
Trikafta, the combination of elexacaftor (VX-445), tezacaftor (VX-661) and ivacaftor (VX-770), was approved for therapy of cystic fibrosis (CF) patients with at least one allele of the CFTR mutation F508del. Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator...
We present nine diallelic models of genetic conflict in which one allele is imprintable and the other is not to examine how genomic imprinting may have evo... HG Spencer,MW Feldman,AG Clark - 《Genetics》 被引量: 103发表: 1998年 加载更多来源...
Vertebrate virus genomes often suppress the frequency of cytosine next to a guanine in 5'->3' single-stranded nucleic acid (CpG) and uracil next to an adenine in 5'->3' single-stranded RNA (UpA) dinucleotides, which is strongly linked to the evasion of interferon-induced, zinc-finger ...
We excluded 66 highly polymorphic mtDNA variants previously described in the mtDNA control region at positions: 303–315, 522–523, 574, 16 180– 16 193 and 16 519.22,28 We excluded three known variants because of insertion or deletion of a single nucleotide (indels), as allele frequen- ...
Unless otherwise described, all errors shown in (a–f) are SE derived from fitting the model to mean ± SEM of bond lifetimes (Supplementary Table 3). Source data are provided as a Source Data file. Full size image It is worth pointing out that the above results not only support ...