In patients meeting criteria for treatment, regimens are based on a backbone of an anti-CD20 agent (rituximab, R; ofatumumab; obinutuzumab, G). In the case of FL, anti-CD20 therapy is combined with either chemotherapy (BR/G or R/G-CHOP) or R-lenalidomide. Regarding the initial choice of...
Why it's important This measure shows the cash we generate that is available to return to shareholders or reinvest in the business, as well as our effectiveness in converting our earnings to cash through effective working capital control and investment discipline. B Growth excluding legal ...
With the emergence of high-efficacy therapies, relapsing multiple sclerosis (RMS) is becoming a thing of the past. First the immune trafficking inhibitor natalizumab, then the anti-CD20 B cell-depleting ocrelizumab and ofatumumab have been game-changers, dramatically improving the long-term outlook ...
So far, the drug has been a potent weapon against CLL. In some research, ibrutinib has been shown to be more effective than chlorambucil, a chemotherapy treatment. One study achieved an overall response rate of 92%.4 While tolerance is generally good, adverse side effects can include higher ...
Safety, tolerability and activity of ofatumumab, bendamustine and dexamethasone combination as first-line treatment of mantle-cell lymphoma in the elderly: a multicenter study. Blood (ASH Annual Meeting Abstracts) 2011; 118: 1647. Google Scholar Vose JM, Loberiza FR, Bociek G, Bierman P, ...
Splenectomy is as effective as rituximab, with somewhat longer-lasting remissions (Table 1).8, 9, 16, 20, 21, 22 Use of splenectomy has gradually declined, however, to <10% of cases, mainly due to the increased infection risk, particularly in the first year. This risk is not eliminated...
73 While most immunosuppressive or cytotoxic agents used in WAIHA have been tested in CAD, the efficacy is generally lower. Treatments reported to have nearly no response are azathioprine and cladribine.65,74 Treatments reported to be effective but published as single case reports are bortezomib, ...
For people with relapsing-remitting multiple sclerosis (MS), a new study has found that the drug ofatumumab is more effective than teriflunomide at helping people across racial and ethnic groups reach a period of no disease activity. The study is publish
Bruton’s tyrosine kinase inhibitors are effective in many B-cell malignancies including indolent B-cell NHL and CLL, with generally favorable but unique safety profiles. Continuous monitoring and management of AEs (Table 6) as well as potential drug interactions over the course of therapy (Table ...
BEMA (BioErodable MucoAdhesive) Fentanyl is effective in delivering a high strength opioid pain reliever, fentanyl, very quickly and conveniently. BREAKTHROUGH FOR CANCER PAIN The lozenge was developed for patients with breakthrough cancer pain or those who were already taking opiates for persistent ...