R; ofatumumab; obinutuzumab, G). In the case of FL, anti-CD20 therapy is combined with either chemotherapy (BR/G or R/G-CHOP) or R-lenalidomide. Regarding the initial choice of anti-CD20 agent, the GALLIUM study compared R-chemotherapy to G-chemotherapy in 1202 ...
Experimentation is ongoing to see if new combinations may work better than established treatments. For example, aNew England Journal of Medicinestudyof more than 500 CLL patients found that combination therapy of ibrutinib and rituximab may be more effective than FCR (aprogression-free survival rateof...
A phase III study of subcutaneous ofatumumab in patients with pemphigus vulgaris, a rare autoimmune skin disorder, also began. We also submitted a regulatory file to the EMA, for a variation to the marketing authorisation for Volibris – our medicine for pulmonary arterial hypertension (PAH) – ...
Ofatumumab in rituximab-refractory autoimmune hemolytic anemia associated with chronic lymphocytic leukemia: a case report and review of literature Clin Lymphoma Myeloma Leuk, 13 (4) (2013), pp. 511-513 View PDFView articleView in ScopusGoogle Scholar 44 V Pejsa, M Lucijanic, A Vrkljan Vuk, ...
Five drugs have been recently approved for use in CLL: ibrutinib, idelalisib, obinutuzumab, ofatumumab, and venetoclax. There is no evidence from randomized trials to suggest that any of these agents increases the absolute risk of AIHA.48,60, 61, 62 There is a flare phenomenon described among...
Five drugs have been recently approved for use in CLL: ibrutinib, idelalisib, obinutuzumab, ofatumumab, and venetoclax. There is no evidence from randomized trials to suggest that any of these agents increases the absolute risk of AIHA.48,60, 61, 62 There is a flare phenomenon described among...
In 2014, ibrutinib was the first BTK inhibitor to gain Health Canada approval based on the RESONATE trial, which demonstrated superior progression-free survival (PFS) and overall survival (OS) compared to ofatumumab (an anti-CD20 monoclonal antibody) in patients with relapsed CLL [9]. Notably, ...