CAR-T therapy is available for children with B-cell acute lymphoblastic leukemia when first-line systemic chemotherapy fails, relapses after hematopoietic stem cell transplantation, or second and subsequent relapse. It can significantly reduce the risk of relapse in children with leukemia who have expe...
CAR-T cell therapy has been an effective treatment for some forms of cancer—particularly for hard-to-treat or recurrent cancers. In fact, one study found that 18% of people with relapsing, treatment-unresponsive chronic lymphocytic leukemia (CLL) experienced full remission after a single CAR-T ...
The impressive clinical results of CAR T-cell therapy was achieved in adult and children patients.However, researchers suggested that this approach has been less effective in some patients with non-viral cancers. In this review, we discussed about existing signaling pathways between CART-Cell and ...
David Maloney, MD, PhD, medical director, Cellular Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, discusses the results of the ZUMA trial and how chimeric antigen receptor CAR T-cell therapy is changing the treatment landscape for non-Hodgkin lymphoma....
lasting immune protection. ‘‘The same principle applies to CAR-T cells: the higher the number of memory cells, the more effective the anti-tumor response and the better the clinical outcome. The state of differentiation of CAR-T cells is therefore a key factor in the success of ...
“Leukemic cell pyroptosis induced by CAR-T cell therapy triggers CRS in patients,” Huang’s team concluded. “Every step they describe is supported by clear-cut logic and data,” said Munich’s Hornung. “The experiments need to be confirmed by other labs,” he cautioned, but...
Treatment with Chimeric Antigen Receptor-T cell (CAR-T) therapy is revolutionizing the management of patients with relapsed/refractory aggressive B-cell lymphoma by providing an effective alternative to the standard of care. Yet, the implementation of CAR-T treatment has a...
How Do Exhaust Headers on a Car Work? Editor's Picks Why Is There a Crack in the Liberty Bell? How American Exceptionalism Works Black Loyalists Fought for Their Freedom During the American Revolution A River Runs Through It The 9 Longest Rivers in the World: From the Nile to the Congo ...
CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses have
The main goal of a case-series study is to generate hypotheses that can be further validated by rigorous statistical methods. Conclusions and perspectives The effective use of the SEER database for cancer research depends on the appropriate application of study designs and statistical models. The ...