Now he had the tools to prove it. Over the years, Lowell had developed an expertise in cutting-edge genetic engineering techniques that allowed him to target and delete specific genes and create new strains of “knockout” mice—meaning specific genes had been knocked out in an embryo, causin...
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest. Cancer Res. 64, 4487–4497 (2004). Article CAS PubMed Google Scholar Munoz-Gamez, J. A. et al. Inhibition of poly (ADP-ribose...
They plan to send out breeding pairs of the tion, but not nearly as much as do wild mice. Depending on the strain, the mice survived first strains by the end of this year, with up to Huge chunks of the genomes of these strains between 4 and 28 days after infection. On the 100 ...
encorafenib were 3.4-fold higher in the Abcb1a(−/−)/Abcb1b(−/−) mice,1.8-fold higher in the Abcg2(−/−) mice, and 16.1-fold higher in the Abcb1a(−/−)/Abcb1b(−/−)/Abcg2(−/−) knockout mice compared with wild-type mice (Wang et al., 2018)....
They plan to send out breeding pairs of the tion, but not nearly as much as do wild mice. Depending on the strain, the mice survived first strains by the end of this year, with up to Huge chunks of the genomes of these strains between 4 and 28 days after infection. On the 100 ...
The probe, with a uniform size of 30.2 ± 2.9 nm, exhibited high labeling efficiency and good stability. Computed Tomography (CT) scans of AS gene knockout mice induced by a high-fat diet showed that the imaging probe accumulated more effectively in apoptotic macrophages with the addition of ...
the knockout of the Pfs47 gene showed an interaction with the mosquito's immune system, in which, after the silencing of TEP1 –the gene responsible for the melanin reaction in the mosquito –, there was a complete reversal of melanin presence and an increase in the intensity of parasitic ...
Choleris, E.et al.An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor-α and -β knockout mice.Proc. Natl. Acad. Sci. U. S. A.100, 6192–6197 (2003). ArticleADSCASPubMedPubMed CentralGoogle Scholar ...
Moreover, in one study with transgenic dystrophin-deficient mice with nNOS overexpression, it was found that the positive effect of nNOS-dependent gene therapy was not associated with the localization of the newly formed enzyme: cytoplasmic nNOS was as effective as sarcolemmal nN...
For example, “We tested the hypothesis that KLF2 knockout mice would show deficiencies in heart development” is an assumption or prediction, not a hypothesis. The research hypothesis at the basis of this prediction is “the product of the KLF2 gene is involved in the development of the ...