New insights into how genetic mutations arisetext editorEmerging Infectious Diseases
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Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells Cancer Res, 61 (2001), pp. 6635-6639 View in ScopusGoogle Scholar Hou 2014 Hou Z, Matherly LH Biology of the major facilitative folate transporters SLC19A1 and SLC46A1 Curr Top Mem...
How do unimportant traits evolve?Evolution of TraitsTraits evolve via mutation. Mutations arise in the genetic code which can be either positive, negative, or neutral. Positive mutations will be selected for and negative mutations will be selected against. Neutral mutations will not affect selection....
Why are mutations not a significant source of variation? Why does radiation cause genetic mutations? List three possible ways mutations can be acquired. The NSRD mutation is a harmful mutation. Why might someone with this mutation not actually be affected? How do germline mutations differ from som...
A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets. J. Exp. Med. 216, 133–151 (2019). CAS PubMed PubMed Central Google Scholar Gibbs, A. et al. MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-...
These signal molecules are transported to systemic tissues, where they induce systemic acquired resistance (SAR). SAR is associated with the systemic reprogramming of thousands of genes to prioritize immune responses over routine cellular requirements. Epigenetic modifications and site-specific chromatin ...
Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2 Exp. Hematol., 44 (2016), pp. 1072-1084 View PDFView articleView in ScopusGoogle Scholar Bysani et al., 2017 M. Bysani, A. Perfilyev, V.D. de Mello, T. Ronn,...
some land mammal acquired mutations that let it adapt to life in the ocean—and its descendants are the whales we know and love. But plasticity offers another possibility: The gene itself doesn’t have to mutate in order for a new trait to surface. Instead, something in the environment coul...
How are inherited mutations different from acquired mutations? Is dog DNA structure similar to humans? How do biological factors and cultural behavior influence human evolution? Why do all the normal cells in the human body have the same number of chromosomes?