Ultraviolet (UV) radiation is a ubiquitous component of the environment that has important effects on a wide range of cell functions. Short-wavelength UVB radiation induces sunburn and is a potent immunomodulato
How is DNA structure similar to a protein? In what way might a point mutation in DNA make a difference in the function of a protein? How do animals get amino acids? How are RNA and DNA used to make proteins? Why don't all cells make all proteins coded for their DNA?
Genes with functions such as enzymes, transporters and transcription factors often survive in duplicate. However, the mechanism of duplication is important: genes that are part of complex cellular networks are more easily duplicated by whole-genome duplication (WGD) than by small-scale duplication (SS...
By leveraging the self-cleaving intein system, target proteins are efficiently released directly off the magnetic bead without recombinant tags, additional reagents, or enzymatic steps. This feature significantly accelerates the overall purification process, making it much more suitable for high-throughput ...
Of particular interest is the ability of GVAs inhibit long-distance electrical and Ca 2+ signalling probably through inhibition of GLUTAMATE RECEPTOR-LIKE proteins (GLRs), the effect which is surprisingly very similar to inhibition of nerve impulse transmission in animals or human. However, GVAs ...
These effects may be resolvable in properties of reconstructed ancient enzymes. By use of paleogenetics, whereby the sequences of ancestral biomolecules are statistically inferred and resurrected in the laboratory, connections may be made between the global-scale effects of the Great Oxidation Event, ...
Receptor proteins are a class of proteins that act as molecular sensors. They play a vital role in cell signaling by detecting stimuli from the outside world and transmitting this information to the cell nucleus. One of their most important functions is to regulate gene transcription, the ...
Molecularly imprinted polymers (MIPs) are synthetic polymers that are tailor-made for specific recognition. As antibodies and enzymes, their three-dimensional structure and functional groups with a specific orientation are orchestrated to allow a selective molecular binding. Functional monomers interact with...
By leveraging the self-cleaving intein system, target proteins are efficiently released directly off the magnetic bead without recombinant tags, additional reagents, or enzymatic steps. This feature significantly accelerates the overall purification process, making it much more suitable for high-throughput ...
is that it is mostly the result of the accumulation of toxic Ab-like peptides in the brain that leads to neurodegeneration. The dominant thinking is that these peptides are produced endogenously, our own brain proteases break down the amyloid precursor proteins generating the toxic Ab peptides...