Mutational analysis of Akkermansia muciniphila identified genes important for growth in mucin and gut colonization. Mucin-degrading capabilities are essential for the bacterium to compete with other members of the microbiota, and mucin metabolism by A.muciniphila resulted in reduced transcription of ...
The gut bacterium Akkermansia muciniphila is an excellent example of such a regulator. Abundance of A. muciniphila is decreased in obese (and diabetic) mice, while reintroduction of the bacterium by oral gavage improves epithelial barrier function and reduces diet-induced obesity (Everard et al....
Akkermansia [9,29,31,41] 6 muciniphila [21,43] Desulfovibrio [8,16,28,39] 6 desulfuricans [34] longreachensis [35] vietnamensis [35] Eubacterium [6,8,26,29,41] 6 infirmum [34] limosum [34] Leptotrichia [22,28,34] 6 hofstadii [13,16] buccalis [16] a The ranki...
Finally, numerous mucolytic bacteria are found among the intestinal commensal microbiota, such as Akkermansia muciniphila, Bacteroides thetaiotaomicron, and Bifidobacterium bifidum (Geerlings et al., 2018; Ouwerkerk et al., 2013; Sicard et al., 2017). Some bacterial gut pathogens have evolved ...
Keywords: Akkermansia muciniphila; mucin; gut microbiota; ecological niches; digestive tract; human breast milk 1. Introduction The microbial community in the human gut plays a role in the balance between health and disease. The gastrointestinal (GI) microbiota has recently emerged as an important ...
barrier, as the natural polyphenol affects the gut barrier through numerous other pathways, such as indirect modulation of the endocannabinoid system, which has been shown to correlate with the promotion of beneficial GM including Ruminococcacaea and Akkermansia Muciniphila [185] (Figure 4, Table ...