Mutational analysis of Akkermansia muciniphila identified genes important for growth in mucin and gut colonization. Mucin-degrading capabilities are essential for the bacterium to compete with other members of the microbiota, and mucin metabolism by A.muciniphila resulted in reduced transcription of ...
Lee et al. observed that the amount of Akkermansia muciniphila (phylum Verrucomicrobia) and Desulfovibrio spp. (phylum Proteobacteria) increased in response to HFD in young rats independently from sex and in aged female rats, but not in aged male rats (Lee et al., 2018). Another experiment ...
Akkermansia muciniphila ( A. muciniphila ; Akk), a Gram-negative anaerobic bacterium in the intestine, can potentially improve metabolic syndrome.This study investigated the effect and underlying mechanisms of an A. muciniphila subtype ( A. muciniphila sub ; Akk sub ) on OLZ-induced ...
In this regard, dysbiotic GM containing Escherichia coli, Klebsiella, and Shigella have been reported with higher abundance [77] while beneficial GM including Akkermansia muciniphila and Faecalibacterium prausnitzii are reduced [78]. Numerous external pro-inflammatory lifestyle factors are known as ...
Boulardii, Enterobacter halii, and Akkermansia muciniphila. As mentioned earlier, A. muciniphila administration daily for 4 weeks to obese/diabetic mice reversed obesity, insulin resistance, and type 2 diabetes [115]. Additionally, A. muciniphila increases the mucus layer thickness in the gut ...
VB3 directly activates GPCR109A, which also recognizes butyrate, leading to similar effects, notably on lipid regulation. Reintroduction of Akkermansia muciniphila in GF mice partially restored the lack of nicotinamide-producing species [100]. Another study suggests the involvement of Methylobacteriace...