The gut microbiome is associated with psychiatric disorders; however, the molecular mechanisms mediating this association are poorly understood. The ability of host genetics to modulate the gut microbiome may be an important factor in understanding the association. In this study, we aimed to evaluate ...
et al. Complex host genetics influence the microbiome in inflammatory bowel disease. Genome Med. 6, 107 (2014). Article PubMed PubMed Central Google Scholar Jang, K. K. et al. Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization. Cell Host Microbe ...
but the influence of host genetics is understudied. To investigate the role of host genetics upon the gut microbiota structure, we performed a longitudinal study in which we evaluated the hindgut microbiota and its
Interest in the interplay between host genetics and the gut microbiome in complex human diseases is increasing, with prior evidence mainly being derived from animal models. In addition, the shared and distinct microbiome features among complex human diseases remain largely unclear. Results This analysis...
The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associat...
Interactions between host gene expression and microbiome in human health The bidirectional interactions between host genetics and gut microbiome are recognized, exerting a profound influence on host health [93]. For example, host gene AMY1 encoding the salivary amylase enzyme has been revealed to be ...
Diet interventions may dominate over host genetics to influence the incidence and development of metabolic diseases [23, 24], which is, at least in part, due to the modulations of gut microbial communities and metabolism. Thus, understanding the effects of nutrient-altered microbial metabolites on ...
The mammalian gut is home to a diverse microbial ecosystem, whose composition affects various physiological traits of the host. Next-generation sequencing-based metagenomic approaches demonstrated how the interplay of host genetics, bacteria, and environ
2021. "Examining the Interaction of the Gut Microbiome with Host Metabolism and Cardiometabolic Health in Metabolic Syndrome" Nutrients 13, no. 12: 4318. https://doi.org/10.3390/nu13124318 APA Style Galié, S., Papandreou, C., Arcelin, P., Garcia, D., Palau-Galindo, A., Gutiérrez-T...
The human gut microbiome is a complex ecosystem that is involved in its host’s metabolism, immunity and health. Although interindividual variations in gut microbial composition are mainly driven by environmental factors, some gut microorganisms are heri