inducing symptoms characteristic of liver disease, insulin resistance, osteopenia, and myopathy. Although these physiological responses can involve the microbiome on Earth, host-microbiota interactions during spaceflight are still being elucidated. We explore murine gut microbiota and host gene expression...
In this chapter we discuss the interplay between diet, the gut microbiota and the host immune system in regulating both metabolic and inflammatory processes with particular emphasis on how this interaction impinges on the development of the metabolic syndrome....
Human genetic variation affects the gut microbiota through a complex combination of environmental and host factors. Here we characterize genetic variations associated with microbial abundances in a single large-scale population-based cohort of 5,959 genotyped individuals with matched gut microbial metagenome...
Gas chromatography-mass spectrometry (GC–MS), liquid chromatography-mass spectrometry (LC-MS), and capillary electrophoresis-mass spectrometry (CE-MS), three powerful tools that can be utilized to study host-gut microbiota interactions, are included with examples of their applications. After obtaining...
摘要:Accumulating evidence suggests that the bile acid regulates type 2 diabetes mellitus (T2DM) through gut microbiota-host interactions. However, the mechanisms underlying such interactions have been unclear. Here, we found that glycoursodeoxycholi...
Previous studies have confirmed that transplanted microbiota may be able to maintain their ecological stability in the host animal for 6 months [78] to 1 year [79]. This suggests that these models are robust enough to study the mechanism of human diseases, at least in the acute phase, althou...
研究表明,母乳中的补体成分能够通过C1依赖的、抗体独立的机制直接裂解革兰阳性肠道共生菌群(Gram-Positive Gut Commensal Microbiota)的特定成员,导致膜攻击复合物(Membrane Attack Complex)的沉积和随后的细菌裂解。通过选择性消除肠道共生...
the microbiome. We develop LOCATE (Latent variables Of miCrobiome And meTabolites rElations), a machine learning tool to predict the metabolite concentration from the microbiome composition and produce a latent representation of the interaction. This representation is then used to predict the host ...
Large-scale metabolic interaction network of the mouse and human gut microbiota. Sci Data. 2020;7(1):1–8. Google Scholar Dohlman AB, Shen X. Mapping the microbial interactome: statistical and experimental approaches for microbiome network inference. Exp Biol Med. 2019;244(6):445–58. ...
Discoveries made in the past 5 years indicate that the composition of the intestinal microbiota has a major influence on the effectiveness of anticancer immunosurveillance and thereby contributes to the therapeutic activity of immune-checkpoint inhibitors that target cytotoxic T lymphocyte protein 4 (CTLA...