Define homeobox gene. homeobox gene synonyms, homeobox gene pronunciation, homeobox gene translation, English dictionary definition of homeobox gene. n. Any of a large family of genes containing a characteristic sequence of nucleotides, called the "homeo
When they created a wound on the back, they found that only one of two lineages of fibroblast — expressing homeobox protein engrailed-1 — was responsible for the formation of most scar tissue. FromNature Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ...
Definition A sequence of DNA conserved across species that is found within genes involved in the regulation of development. They generally encode transcription factors which typically switch on cascades of other genes. Endocrine Disorders of Development and GrowthDefinitionA sequence of DNA conserved ...
Normal homeobox gene expression is altered in various disease states. For example, decreased expression of Cdx2 is detected in the intestinal epithelium of patients with colorectal cancers and decreased Meox2 expression is detected in brain endothelial cells of patients affected by Alzheimer's disease...
Other Homeobox-Containing Gene Families The POU gene family is named for the acronym of the first genes identified:Pit1, a gene uniquely expressed in the pituitary;Oct1andOct2; andUnc86, a gene expressed in a nematode. Genes of the POU family contain, in addition to ahomeobox, a region ...
Definition Homeobox genes are a class of developmental regulatory genes that encode homeoproteins. Homeoproteins function as transcription factors to regulate downstream targets, turning on (activating) or turning off (repressing) other genes that in turn regulate developmental processes. Aberrant expression...
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Finally, many homeobox gene mutations are (or will be) embryonic or perinatal lethal, making analysis of the development of adult organs particularly challenging. This current state of affairs makes it difficult to develop mechanistic models for the function of a given homeobox gene, especially in ...
Therefore, transcriptional repres- sion appears to be a common mode of action for WOX proteins, but both the type of target gene and the functional domain(s) involved in repression appear to differ. Future research will need to unravel which of these motifs have a regulatory function. ...
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene