M2 type TAM and regulatory T cells (Treg) are immunosuppressive cells that can promote tumor progression via inhibiting anti-tumor immunities44,45. It has been uncovered that the hypoxic TME could promote the recruitment of Treg into tumors12and tune TAM ...
Hydrogen peroxide (H2O2) solution at different concentrations was used to mimic the ROS exposure levels at different time points, as shown in Table 1. Aliquots of 100 μL of hollow spheres suspensions were pipetted out and dried overnight. The ROS-treated samples were then resuspended in the...