et al. Superoxide dismutase 1-modified dental pulp stem cells alleviate high-altitude pulmonary edema by inhibiting oxidative stress through the Nrf2/HO-1 pathway. Gene Ther 31, 422–433 (2024). https://doi.org/10.1038/s41434-024-00457-x Download citation Received15 February 2024 Revised19 ...
HO-1基因被认为是一种应对体内血红素蓄积的管家基因(house-keeping gene). 近年来大量的研究发现HO-1具有抗炎、抗凋亡、抗增生反应等多种保护作用. HO-1不仅可以在机体生理状态下发挥作用, 更为重要的是他可以在机体非正常状态包括应激状态下被诱导, 被认为是在细胞受损时维持其氧化和抗氧化动态平衡的关键因素. ...
HO-1 gene transfer was found to be protective against lung fibrotic injury in a mouse lung fibrosis model [32]. This protective effect has been attributed to the anti-proliferative effects of CO. However, the involvement of Nrf2/HO-1 in the inflammatory response of joint capsule fibrosis has...
AM1241 has the potential to stimulate chondrocyte proliferation and up-regulate cartilage-specific gene expression. Furthermore, AM1241 has anti-inflammatory effects by inhibiting LPS-induced abnormal up-regulation of TGF-β1, TNF-α and IL-6. In addition, AM1241 can promote the synthesis of cart...
resulting in unbinding of Bach1 from the Stress-Responsive Elements (StREs) of theHMOX1gene, leading to increased transcription of HO-1 in the cell. Simultaneously, the increased ROS levels, cause Kelch-like ECH-associated protein 1 (Keap1) detachment from NF-E2-related Factor 2 (Nrf2) all...
How does HO-1 interact or cross-regulation in different modes of cell death? How to regulate the dual character of HO-1 in ferroptosis? How to develop precise strategies for the toxicity of HO-1 targeted therapy? Introduction Diabetes mellitus (DM, abbreviations are defined in Table1) is a...
利拉鲁肽与胰高血糖素及其类似物具有较高的同源性,进入脑组织后能与相关受体结合并激活Nrf2/HO-1信号通路,进而减少氧化应激产物生成,提高谷胱甘肽、血红素氧合酶、超氧化物歧化酶等Ⅱ相解毒酶,促进血管生成,从而保护糖尿病合并脑缺血损伤的神经细胞。 关键词: 脑缺血;糖尿病;NF-E2相关因子2;血红素氧化酶-1;氧化...
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These incurable conditions damage brain functions like mobility, cognition, and emotional regulation, but medication, gene therapy, and physical therapy can manage symptoms. Disruptions in cellular signalling pathways, especially those involving oxidative stress response, memory processing, and neurotransmitter...
How does HO-1 interact or cross-regulation in different modes of cell death? How to regulate the dual character of HO-1 in ferroptosis? How to develop precise strategies for the toxicity of HO-1 targeted therapy? Introduction Diabetes mellitus (DM, abbreviations are defined in Table1) is a...