HGT Methods, a bimonthly journal, focuses on the applications of gene therapy to product testing and development. HGT Clinical Development, a quarterly journal, serves as a venue for publishing data relevant to the regulatory review and commercial development of cell and gene therapy products....
gene transferboundary-workHuman gene therapy (HGT) aims to cure disease by inserting or editing the DNA of patients with genetic conditions. Since foundational genetic techniques came into use in the 1970s, the field has developed to the point that now three therapies have market approval, and ...
Human Gene Therapy HGT <id>http://www.zotero.org/styles/human-gene-therapy</id> <author> <name>Patrick O'Brien</name> </author> <categorycitation-format="numeric"/> <categoryfield="biology"/> <categoryfield="medicine"/> <issn>1043-0342</issn> <eissn>1557-...
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141–151 (1999). 2. Thompson, R. H. et al. Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic...
The widespread usage of antimicrobials has driven the evolution of resistance in pathogenic microbes, both increased prevalence of antimicrobial resistance genes (ARGs) and their spread across species by horizontal gene transfer (HGT). However, the impac
the gene prediction depends on the read length, computational tools and reference database; (f) the lack of a reference database often prevents accurate assessment of sequences or designates them as ORFans; (g) only the major bacterial populations are revealed; and (h) detection of HGT events...
The widespread usage of antimicrobials has driven the evolution of resistance in pathogenic microbes, both increased prevalence of antimicrobial resistance genes (ARGs) and their spread across species by horizontal gene transfer (HGT). However, the impac
Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy Article Open access 09 September 2021 Hematopoietic stem cell transplantation in children with mucopolysaccharidosis IVA: single center experience Article 14 October 2024 Treatment of ...
Sanofi-Genzyme’s India Charitable Access Program (INCAP), Shire HGT's charitable access program in partnership with Direct Relief (a non-governmental organization), and Protalix Biotherapeutics have provided access to enzyme replacement therapy for lysosomal storage diseases in India [111]. Apart from...
CD gene therapy has historical significance, as the disorder represents both the first clinical trials for a neurodegenerative disorder (ICV administration of lipid-encapsulated plasmid DNA (LPD) containing hASPA cDNA; Leone et al., 2000), and the first AAV-based FDA-approved clinical trial for ...