hnRNPA1A是一种多结构域蛋白,在N端有两个RNA识别基序(RRMs)和一个非结构化的C端区域,该区域富含G/S-Y/F-G/S基序,被认为是参与相分离或相变功能的低复杂度结构域(LCD)。该区域具有影响RNA结合的RGG基序、核定位序列和几个朊...
近日,海军军医大学国家肝癌科学中心王红阳院士、陈磊教授团队在Cell Reports Medicine上发表研究论文LTA4H Improves Tumor Microenvironment and Prevents HCC Progression via Targeting HNRNPA1/LTBP1/TGF-β Axis。该研究发现了LTA4H在HCC进展中...
Here we investigate how heterotypic protein–RNA interactions modulate the condensation and the liquid to amyloid transition of hnRNPA1A, a protein involved in amyothropic lateral sclerosis. In the absence of RNA, formation of condensates promotes hnRNPA1A aggregation and fibrils are localized at the...
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Deletion of the hnRNP A1 primary binding site dramatically modified the expression pattern: the mRNA levels and luciferase activities of the deletion mutant were independent from hnRNP A1. These results conclusively demonstrate that the 71 nt region in the 3′ UTR of CYP2A5 mRNA can confer hnRNP...
Nielsen AF, Leuschner PJ & Martinez J (2007) Not miR-ly a splicing factor: hnRNP A1 succumbs to micr- oRNA temptation. Nat Struct Mol Biol 14, 572-573.Nielsen AF, Leuschner PJ, Martinez J (2007) Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation . Nat Struct...
Anti-hnRNP A1 (isoform A1-A) antibody生产厂家 全球有 2家供应商Anti-hnRNP A1 (isoform A1-A) antibody国内生产厂家 供应商联系电话电子邮件国家产品数优势度 北京冬歌博业生物科技有限公司1861586486@qq.com中国664858 北京百奥创新科技有限公司3007606172@qq.com中国600258...
hnRNPA1Alternative splicingWarburg effectColorectal cancerAlternative splicing of pyruvate kinase gene (PKM) results in a higher PKM2/PKM1 ratio that contributes to the Warburg effect and reversing the Warburg effect has opened novel avenues for cancer treatment. miR-206 functions as a tumor suppressor...
hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structure 喜欢 0 阅读量: 7 作者:Damgaard,C. K.,Tange,T. O.,Kjems,J.年份: 2002 收藏 引用 批量引用 报错 分享 ...
protein-protein interactions; host-virus relationships; IAV replication; nucleoprotein; hnRNPA11. Introduction Influenza A is a zoonotic intracellular RNA virus that imposes a significant disease burden, with approximately 3–5 million infections annually worldwide. Currently, available intervention strategies...