[1] Editorial The Role of HMGB1 in Immunity [2] High-mobility group box 1 protein (HMGB1) nuclear weapon in the immune arsenal [3] High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair [4] HMGB1...
immunofluorescence staining; the total number of cells and the percentage of neutrophils in bronchoalveolar lavage fluid (BALF); the levels of pro-inflammatory cytokines tumor necrosis factor-α(TNF-α) and interleukin-1β (IL...
HMGB1, IL-1β, NLRP3 inflammasome, VSMC, TLRs, RAGEVascular smooth muscle cells (VSMCs) are the major cell type in the blood vessel walls, and their phenotypic modulation is a key cellular event driving vascular remodeling. Although high mobility group box-1 (HMGB1) plays a pivotal role ...
where it plays an important role in chromatin structure and gene expression. The translocation of HMGB1 to the cytoplasm is regulated by post-translational modifications such as acetylation, methylation and phosphorylation (1). Because of the lack of a secretion signal, HMGB1 is actively secreted...
HMGB1, high-mobility group box 1 protein; IL, interleukin; LPS, lipopolysaccharide; RAGE, receptor for advanced glycation end-products; ROS, reactive oxygen species; TLR, Toll-like receptor. Cellular & Molecular Immunology Dual-function alarmins in the heart of inflammation and disease D Berthe...
Chestnut Studying 摘要 High mobility group protein 1 (HMGB1) is considered to be the primary inflammatory factor triggering immune paralysis in late-phase sepsis. In this study, however, we wanted t…
(6). HMGB1 is expressed at high levels in almost all cells (2, 4). It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins (1, 7, 8). It is ...
Objective To investigate the effects of NF-κB on the expression of high mobility group protein 1(HMGB1)in lipopolysaccharide induced acute lung injury rats.Methods LPS(5mg/kg,ip)induced acute lung injury model was used in our experiment,72 healthy male Sprague-Dawley rats,weighing180-220 g,were...
The mechanism of HMGB1 inhibitor on T lymphocytes and monocytes in the sepsis mice Zhao Xu, Chen Zhaofang* PDF (PC) 340 摘要/Abstract 摘要:目的 探讨高迁移率族蛋白B1(high modility groupbox 1,HMGB1)抑制剂对脓毒症T淋巴细胞和单核细胞的作用机制。 方法 将30只C57BL/6雄性小鼠随机分为3组,每组...
The expression of RAGE by activated endothelia promotes leukocyte recruitment, through the interaction of RAGE with myeloid cells that express the β2-integrin MAC1, and this is augmented in the presence of S100 proteins. Macrophages also express HMGB1 at the cell surface when they are activated,...