C57BL/6Smoc-H2-Aatm1(HLA-DRA*0101)H2-Ab1tm1(HLA-DRB1*0401)Smoc 目录号 NM-HU-241519 品系状态 在研 加入购物车 导出PDF 基因信息 基因名H2-Aa 基因曾用名 Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha NCBI ID 14960 MGI ID 95895 Ensembl ID ENSMUSG00000036594 Pubmed H2-Aa ...
(1995) HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus. European Journal of Immunogenetics, 22, 289.Tait BD,Drummond BP,Varney MD.HLA-DRB1 * 0401 is associated with susceptibility to insulin-dependent diabetes mellitus ...
哪些细胞系能够高表达HLA-DR4(HLA-DRB1*0401)?要具体的细来自胞系名称?谢谢!网友 1 最佳答案 回答者:网友 主要表达在抗原提呈细胞上,比如说DC细减攻剂头笔始香失胞,B细胞和巨噬细胞。常见的B细胞系: Raji, Daudi巨噬细胞:U-937, 小鼠的Raw264.7DC细胞好像没有细胞系展达从径。。我来回答 提交回答 重置...
目的 建立携带人HLA-Ⅱ类基因DRα,DRB1 0401 转基因鼠模型.方法 利用受精卵原核的显微注射技术,将HLA-DRα,DRB1 0401 两种基因显微注射至C57BL/6×DBA/1 杂交小鼠受精卵中,并移植到假孕受体鼠的输卵管内,然后应用PCR,Southern 印迹杂交和Northern 杂交方法分析子代鼠中基因的整合及表达情况.结果 实验先后有5 只...
As expected, a significant increase (p value = 0.003) of neutralizing in vitro activity was found in sera of HLA-DRB1∗0401- and ∗0408-positive subjects (median activity = 8462 NU) compared to sera from HLA-DRB1∗0401- and ∗0408-negative patients (median activity = 0) (data not...
HLA-DRB1*03:01/HLA-DRB1*04:01-positive patients had a higher median IAIHG score than HLA-DRB1*03:01/HLA-DRB1*04:01-negative patients (P<0.001). We did not observe associations between HLA alleles and alanine transaminase levels (HLA-DRB1*03:01: P=0.2; HLA-DRB1*04:01; P=0.5); ...
Tait BD, Drummond BP, Varney MD, Harrison LC (1995) HLA-DRB1*0401 is associated with susceptibility to insu- lin-dependent diabetes mellitus independently of the DQB1 locus. Eur J Immunogenet 22:289-297Tait;BD;Drunmond;BP;Varney;MD;et;al.HLA-DRB1 0401 is associated with susceptibility to...
Since myelin basic protein (MBP)111–129 is an immunodominant epitope in humans carrying HLA-DRB1*0401, we investigated the encephalitogenic potential of HLA-DRB1*0401-restricted MBP111–129-specific T cells using HLA-DRB1*0401/DRA*0101 transgenic (Tg) mice. Although we could not detect the ...
HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon- therapy in multiple sclerosis [published correction appears in Am J Hum Genet. 2008;83(4):541]. Am J Hum Genet. 2008... S Hoffmann,S Cepok,V Grummel,... - 《American Journ...
Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients. Arthritis Rheum. 2011;63:2873-83.Snir O, Rieck M, Gebe JA, Yue BB, Rawlings CA, Nepom G, Malmstrom V, Buckner JH. ...