HLA-DQ8基因编码了一种特定的HLA-DQ亚型,它是由HLA-DQA1*03和HLA-DQB1*03:02两个等位基因组成。 HLA-DQ8基因型与自身免疫性疾病的发病风险增加有关。例如,它与1型糖尿病、乳糜泻和类风湿性关节炎等疾病的发病风险增加相关。HLA-DQ8基因型也被认为与一些药物过敏反应的易感性有关。 HLA-DQ8基因型的检测可以...
(2009) HLA-DQ8 (DQB1∗0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice. J. Immunol., 182, 5131-5139.Mangalam, A., Luckey, D., Basal, E., Jackson, M., Smart, M., Rodriguez, M. and David, C., HLA-DQ8 (DQB1*0302)-...
HLA-DQ8 is a specific allele or variant of the Human Leukocyte Antigen (HLA) system that is associated with certain conditions, as indicated by the HLA analysis results in the provided text. AI generated definition based on: Brain and Development, 2005 ...
HLA-DQ2 or HLA-DQ8 Blockers Nearly allCeDpatients carry eitherhuman leukocyte antigenDQ2 or DQ8.39In susceptible individuals, the deamidatedgliadinpeptides bind with high affinity to DQ2 or DQ8 expressed on antigen-presenting cells which, in turn, stimulate gliadin-specificT cells.40The activation...
HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β8 and this generally detects the gene product of DQB1*0302. DQ8 is commonly linked to ...
A.HLA-B27 B.HLA-D03 C.HLA-DQ8 D.HLA-DRl E.HLA-DR2相关知识点: 试题来源: 解析 官方提供 E解析:本题涉及系统性红斑狼疮病因中遗传因素的内容,其中HLA-DR2在SLE患者中的频率升高。HLA-B27与强直性脊柱炎发病有关,HLA-DRl、HLA-DQ3、HLA-DQ8与类风湿关节炎有关。反馈...
HLA-DQ2也就是HLA-DQB*02：01和02：02是高风险，还有HLA-DQ8也是高风险，
就如同欧美人携带特定基因型(如HLA-DQ2/DQ8)更易触发IgE介导的过敏反应,而东亚人群相关基因分布显著不同。同时,我们饮食习惯夜有所不同。我们看美剧的时候,经常看到他们吃早餐的时候,就会涂抹花生酱,然后经常喝牛奶,用牛奶泡麦片等等,以这种高蛋白、加工食品为主。而我们则主要是以植物性饮食为主,过敏原接触...
A. 强直性脊椎炎与B27:正确关联,强直性脊柱炎患者HLA-B27阳性率显著升高。 B. 类风湿关节炎与DR4:正确,HLA-DR4(尤其是DRB1*04)与类风湿关节炎易感性密切相关。 C. Reiter病与B27:正确,反应性关节炎(原Reiter病)与HLA-B27关联明确。 D. 1型糖尿病与DQ8:正确,HLA-DQ8(DQB1*0302)是1型糖尿病的重要遗传风...
下列哪种基因亚型与系统性红斑狼疮发病具有一定的相关性A.HLA-B27B.HLA-DR1C.HLA-DR2D.HLA-DQ8E.HLA-DQ3