结果发作性睡病患者组DQB1*0602基因频率为 40%,与正常对照组9.09%相比较明显增高;未检出DQB1*0401-0402基 因,与正常对照组9.09%相比较,经统计学分析,差异有显著性 (P<0.05)。结论HLA-DQB1*0602基因为发作性睡病人群的易感基 因;HLA-DQB1*0401-0402基因为中国发作性睡病人群的保护基因 关键字:发作性睡病...
而在正常对照组中,DQB1*0602阳性者的△VE/△SaO_2也比DQB1*0602阴性者显著降低(0.13±0.08 vs 0.20±0.14,P=0.002)。且这种差异与AHI无关。但△VE/△PCO_2在发作性睡病患者和正常对照及DQB1*0602阳性者和阴性者之间无显著差异。【结论】猝倒型发作性睡病患者低氧反应性的降低与HLA-DQB1*0602有关。 展开...
目的:多次睡眠潜伏期实验(MSLT)是发作性睡病的诊断标准之一,但是许多其他疾病的患者及健康人也可以显示出积极的MSLT.这些假阳性可能会导致错误的诊断.通过比较MSLT,HLA-DQB1*0602等各预测参数在诊断发作性睡病中的差异,从而找出诊断发作性睡病价值相对较高的指标,以指导临床早期发现,早期诊断及早期治疗.方法:收集1型...
HLA—DRB1 ＊1501和DQB1 ＊0602与新疆哈萨克族HPV感染及食管癌发生的相关性研究
(OR=11036,P>0.05);HLA-DQB1 *0602等位基因的分布频率在哈萨克族中低分化鳞状细胞癌组中的分布频率(0.742)高于高分化鳞状细胞癌组(0.597),差异具有统计学意义(P<0.05).结论 HLA-DRB1 *1501、DQB1 *0301和DQB1 *0602可能是哈萨克族食管鳞状细胞癌的易感基因,HLA-DQB1 *0602与哈萨克族食管鳞状细胞癌的分化...
Conclusion: Passive smoking may be a risk factor for narcolepsy in subjects with HLA DQB1*0602. Future studies could help clarify whether passive smoking is an important etiologic component of narcolepsy among genetically susceptible individuals. 展开 关键词: Case-control study Epidemiology HLA-DQ ...
W. Exceptional stability of the HLA-DQA1*0102/DQB1*0602 αβ protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus. J. Immunol. 1... HLA-DQ alleles are closely associated with susceptibility and resistance to insulin-dependent diabetes ...
(7/24),正常对照组的HLA-DRB1*1501-HLA-DQB1*0602单体型的阳性率为9%(5/55),猝倒发作的发作性睡病患者组的HLA-DRB1*1501-HLA-DQB1*0602单体型的阳性率显著高于正常对照人群(p=0.034);无猝倒发作的发作性睡病患者组的HLA-DRB1*1501-HLA-DQB1*0602单体型的阳性率高于正常对照人群,但无显著统计学意义(p=...
Multiple Sclerosis (MS) is a demyelinating disease associated with the HLA-DR2-related haplotype DRB1*1501, DQB1*0602 in Caucasoids and with DQB1*0602 in DR2-positive Cantonese. However, many MS patients do not have the high-risk HLA-D determinants and alternative genes may contribute to th...
通过比较MSLT、HLA-DQB1*0602等各预测参数在诊断发作性睡病中的差异,从而找出诊断发作性睡病价值相对较高的指标,以指导临床早期发现、早期诊断及早期治疗。方法:收集1型发作性睡病患者共171例和年龄和性别相匹配的正常健康志愿者57例,年龄在19-24岁,以国际睡眠障碍分类第3版作为诊断发作性睡病的金标准。所有参与...