HLA-B5801遗传标记 HLA-B*5801alleleasageneticmarkerforseverecutaneousadversereactionscausedbyallopurinol 研发部张艳 别嘌呤醇作用 用途：治疗痛风、高尿酸血症等相关疾病。机理：抑制黄嘌呤氧化酶的活性 副作用：皮肤不良反应如HSS、SJS和TEN PatientsandControlSubjectsRecruitment 228controlindividuals：(135...
Allopurinol ; Severe dru g eru ption; Allele; HLA—B 5801 别嘌呤醇为治疗痛风或高尿酸症常见 的药 物,可以引起皮肤不良反应,其临床表现为斑疹 (maculopapular eruption,MPE ) ,超敏综合征( hy— persensitivity syndrome ,HSS ) 、Stevens—Johnson 综 ...
The risk of ADR in patients with HLA-B*5801 allele was significantly higher than patients without HLA-B*5801 allele(OR:71.74,95%CI:9.02-570.55,P<0.000). The lesion of skin and its appendents was strongly associated with HLA-B*5801 allele (OR:57.39, 95%CI: 7.11-463.50, P<0.000). ...
HLA-B*5801 基因分型方法,不但能得到高分辨结果,还可显 allele as a genetic marker for severe cutaneous adverse reactionscaused by allopurinol [J]. Proc Natl Acad Sci USA 示 HLA 分子基因高变区的全部核甘酸序列,是发 2005, 102(11): 4134-4139. 现新等位基因的主要鉴定方法[9] 。但由于该法用...
Detection of the HLA B*5801 Allele in Han Chinese with Allopurinol induced Severe Drug Eruption DENG Zhi yuan, YANG Jian, YANG Wen lin Author information + 文章历史 + 摘要 目的:检测中国大陆汉族别嘌呤醇重症药疹病人的HLA B*5801等位基因,并初步评价HLA B*5801等位基因作为遗传标记预测中国大陆...
2012年4月硕士学位论文中国大陆汉族人群别嘌呤醇严重不良反应与HLA_B*5801等位基因的相关性研究Relationshipbetweenallopurinol-inducedseverecutaneousadversereactionandHLA-B*5801alleleinHanChineseofmainlandChina研究方向:过敏性皮肤病学位申请人:邓智远导师:**教授广州医学院·广州2012年5月广州医学院硕士毕业论文目录中文...
In this article we report two cases of allopurinol-induced drug eruptions in patients carrying the HLA-B*5801 allele and review the literature on the association between HLA-B*5801 and allopurinol-induced cADRs based on a MEDLINE and PubMed search 机译:别嘌醇是常用于治疗痛风和高尿酸血症的...
Recently, genome wide association studies showed that there is a strong association between abacavir-induced serious, idiosyncratic, adverse drug reactions (ADRs) and human leukocyte antigen-B*5701 (HLA-B*5701). Studies also found that abacavir-induced ADRs were seldom observed in patients carrying ...
1、hla-b*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol,别嘌呤醇作用,用途:治疗痛风、高尿酸血症等相关疾病。 机理:抑制黄嘌呤氧化酶的活性 副作用:皮肤不良反应如hss、sjs和ten,patients and control subjects recruitment,228 control individuals: (135 allopurinol...
HLA-B*5801 基因分型方法,不但能得到高分辨结果,还可显 allele as a genetic marker for severe cutaneous adverse reactionscaused by allopurinol [J]. Proc Natl Acad Sci USA 示 HLA 分子基因高变区的全部核甘酸序列,是发 2005, 102(11): 4134-4139. 现新等位基因的主要鉴定方法[9] 。但由于该法用...