Also Known As: Tissue Typing, Histocompatibility Testing, HLA Crossmatching Board Approved At a Glance Why Get Tested? Testing is usually performed only in the setting of a planned transplantation where you are either the intended transplant recipient or a possible donor. Testing identifies which hum...
[5]Shiina T , Inoko H , Kulski J K . An update of the HLA genomic region, locus information and disease associations: 2004[J]. Tissue Antigens, 2010, 64(6):631-649. [6]Dilthey AT, Mentzer AJ, Carapito R, e...
Why do we need to test for HLA? In the 1950s it was shown that organ and tissue transplantation could offer a cure for numerous illnesses. But the success of these procedures depends to the matching degree between the patient and their donor for HLA. ...
The genes which comprise the MHC (major histocompatability complex or HLA locus) on the shortarmofchromosome 6are divided into three classes occupying a physical distance of approximately 3600 kb (Figure 4.2). TheHLA antigenscontinue to remain an important set of markers for tissue typing, but...
Tissue typing was performed in 20 patients suffering from intermittent acute porphyria using the lymphocytotoxicity test in a two-step method. The patients belonged to different families and were not related. Compared with the healthy population, an increased frequency of HLA-A10, HLA-A29, HLA-...
Regional lymph nodes for tissue antigen Mucosa-associated lymphoid tissues (eg, tonsils, adenoids, Peyer patches) for mucosal antigen For example, Langerhans dendritic cells in the skin phagocytose antigen and migrate to local lymph nodes. In the lymph nodes, peptides derived from the antigen are...
ConclusionsHLA typing results of puncture tissue are consistent with those of whole blood test.Time after transplantation, infiltration of transplanted nephritis cells and degree of fibrosis may influence the detection of HLA loci.Donor HLA quartile genotyping using transplanted kidney biopsy has some diag...
The randomisation allocation was initiated by staff within the tissue typing labs to maintain physician and patient blinding to HLA Ab status within the SC groups (A1, A2, C in Suppl. Fig. S1), in whom treatment decisi...
Histocompatibility Testing 1980 (1980) Terasaki PI (ed) UCLA Tissue Typing Laboratory, Los Angeles. Google Scholar Histocompatibility Testing 1984 (1984) Albert ED, Baur MP, Mayr WR (eds) Springer, Berlin Heidelberg New York. Google Scholar Histocompatibility Testing 1987 (1984) Dupont B (ed)...
HLA typing by next-generation sequencing - getting closer to reality[J]. Tissue Antigens,2014, 83(2):65-75. [7] Schöfl G, Lang K, Quenzel P,et al. 2.7 million samples genotyped for HLA by next generation sequencing :lessons learned[J]. BMC Genomics,2017,18(1):161. [8] ...