Discusses the abstract of the research paper 'Crossmatched (XMPs) and HLA-Matched (HLA-MPs) Apheresis Platelets May Benefit Refractory Patients without Alloantibodies,' by D.C. Mair, et al, to be presented at the American Association of Blood Banks' 55th Annual Meeting on October 26-29, ...
Pai et al23 used HLAMatchmaker for the prospective selection of platelets for alloimmunized patients in a study of 19 patients. If no suitable platelets could be found by serological matching, patients were randomized to receive either cross-reactive group–matched platelets or HEM (eplet) ...
loss of a previous graft due to immunological reasons in the first year after transplantation, receipt of an organ donated after cardiac death, donor age <5 or >65 years, current or peak panel reactive antibodies (PRA) >25%, platelets <75,000/mm3, an absolute neutrophil count of <1.500/...
Independent roles for platelet crossmatching and HLA in the selection of platelets for alloimmunized patients. Transfusion 1994;34:215-20.RC Friedberg,SF Donnelly,PD Mintz.Independent roles for platelet crossmatching and HLA in the selection of platelets for alloimmunized patients.Transfusion. 1994...
A disadvantage of crossmatching is that crossmatched platelets have a shelf life of only 5 days, so that crossmatch tests must be performed frequently for patients requiring long-term platelet transfusions. An alternative method is the selection of platelets according to the patient's HLA antibody...
Of the 30 transfusions, all HLA-A/B-matched, the cross-match (CM) test was negative in 23 (CM(-)-PC) and weakly positive (CM(+)-PC) in 2, and the CM test was not conducted in 5 (non-CM-PC). The effective rate was higher with CM(-)-PC compared to non-CM-PC (82.6% ...
The efficacy of 30 platelet concentrate (PC) products transfused to a patient with myelodysplastic syndrome (MDS) was evaluated by calculating the 1-hour post-transfusion corrected count increment (1h-CCI). Of the 30 transfusions, all HLA-A/B-matched, the cross-match (CM) test was negative...
Neutrophil recovery was defined as first of 3 consecutive days with absolute neutrophil count more than or equal to 0.5 × 109/L and platelets, more than or equal to 20 × 109/L, unsupported for 7 days. Acute grade II-IV GVHD and chronic GVHD were graded using standard criteria.17,18 ...
Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in ...
Selection of platelets for refractory patients by HLA matching and prospective crossmatching.Transfusion 1992;32:633-40.Moroff G, Garratty G, MacPherson BR, et al. Selection of platelets for refractory patients by HLA matching and prospective crossmatching. Transfusion. 1992;32:633-640....