Using polymerase chain reaction-single strand conformational polymorphism and sequencing, we studied HLA-G gene polymorphism in families from the Centre d'Etude du Polymorphisme Humain in Paris. To understand the function of the HLA-G molecule, cytotoxicity assays were carried out with peripheral ...
摘要: The central dogma of immunology, originally postulated by Paul Ehrlich, is based on the assumption that the immune system does not normally react to "self". Consequently, autoimmunity represents the state in which the natural tolerance to self tissue and cell components terminates....
1a, Fig. 1a,b and Extended Data Fig. 1b,c, respectively). Of total itICs, CD4+ and CD8+ T cells were the most increased subpopulation (approximately doubled) (Fig. 1c,d). Oral l-fuc induced similar changes in tumor fucosylation, growth and itICs (specifically increased CD4+ and ...
Antibodies against the HLA class II molecule, DQβ0603:DQα0103, present in some candidates, represent one such example. Here, we show that peptides derived from amino acids 119-148 of the HLA class I heavy chain are bound to DQβ0603:DQα0103 proteins and contribute to antibody reactivity...
Background HLA-DOB belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane.It is located in intracellular vesicles.DO suppresses peptide loading of MHC class II molecules by...
[1]. Therefore, a first lesson that the HLA system has taught us is that polymorphism can occur preferentially in functional domains of a given molecule with dramatic effects on epitope selection and presentation [4,7]. A more practical question learned from HLA is that the extent of ...
HLA-G mRNA is observed in different adult or fetal human cells and exhibits four alternative forms:... P Moreau,E Carosella,M Teyssier,... - 《Human Immunology》 被引量: 130发表: 1995年 Association between the HLA-G molecule and lymph node metastasis in papillary thyroid cancer Papillary ...
Beyond the increasing complexity of the immunomodulatory HLA-G molecule 2008, Blood Show abstract HLA-G: from biology to clinical benefits 2008, Trends in Immunology Citation Excerpt : Since the first description of HLA-G expression by tumor cells in 1998 [45], numerous studies have been performe...
Antigen processing: HLA-DO – a hitchhiking inhibitor of HLA-DM Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathwa... PE Jensen - 《Current Biology》 被引量: 65发表: 1998年 加载更多来源...
The generation of immune tolerance is a role common to both HLA-G, as a molecule, and the liver, as an organ. This review provides a summary of the evidence implicating HLA-G in liver diseases. In the normal liver, HLA-G transcripts can be detected, but there is no HLA-G protein. ...