The genomic sequence of 34 genes locating in the MHC region revealed allelic mismatching at 1 to 8 additional genes in partially HLA-matched pairs. Also, fully matched pairs were found to have mismatching either
In this issue of Blood , Morishima et al report on the risks of acute and chronic graft-versus-host disease (GVHD), relapse, and mortality associated with mismatching for HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 loci after unrelated donor transplantation for Japanese patients.[1][1]...
We report the results of an analysis of unrelated allogeneic hematopoietic stem cell transplantations (HSCT) in 71 patients with sickle cell disease (SCD) transplanted in EBMT centers between 2005 and 2017. Median age was 9.3 years; graft type was bone marrow in 79% and peripheral blood in 21...
Version 2.0 of the DPB1 T-cell Epitope (TCE) Algorithm [20] was used to determine DPB1 TCE permissive/non-permissive mismatching status and directionality (GvH or HvG). Patient, disease, and transplantation-related variables in the four cohorts were compared using chi-square statistics for categ...
Ayuk F, Diyachenko G, Zabelina T, Panse J, Wolschke C, Eiermann Tet al. Anti-thymocyte globulin overcomes the negative impact of HLA mismatching in transplantation from unrelated donors.Exp Hematol2008;36: 1047–1054. ArticleCASGoogle Scholar ...
[2]Ruxiu, Tie, Tiansong,等. Clinical implications of HLA locus mismatching in unrelated donor hematopoietic cell transplantation: a meta-analysis[J]. Oncotarget, 2017. [3]Ciurea S O , Thall P F , Wang X , et al. Donor-specific anti...
Univariate analyses showed that treatment with the +49 GG was a risk factor for OS in ALL (HR: 0.306, 95 % CI 0.111–0.842, P = 0.022) (Table 4). Cox multivariate analysis considered several variables including the age, sex, HLA mismatching locus, status of disease before HSCT, MRD ...
nr0wtransplantation:HLA-Cmismatchingisassociatedwithastroilg adverseeffectoutransplantationoutcome.Blood,2OO4,104(7): l923 一l930. 15jICetersdorfEW,ArmsettiC,MartinPJ,eta1.LimitsofHLAmi— smatcHnginunrelatedhematopoieticcelltransplantation.Blood,
(MHC) proteins in humans. Accurate typing of HLA genes is particularly important in organ and blood stem cell transplantation where the risk of graft-versus-host diseases is known to increase with mismatching of HLA genes [1]. In addition, many gene-disease associations have been reported [2]...
Impact of HLA class I high-resolution mismatches on chronic graft- versus- host disease and survival of patients given hematopoietic stem cell grafts from unrelated donors Bone Marrow Transplantation ( ) 35, 57–62 ;Selecting a Mismatched Donor No Guidelines for Permissive Mismatching;Takakazu Kawase...