数十年前,科研工作者就发现,HLA的兼容性,对于器官移植的移植排斥的发生率和发生时间有非常重要的影响。一项针对肾移植的调研发现,在A,B,DR这六个位点上(一般每个个体在HLA基因上有等位基因,也就是说,有两个HLA-A,两个HLA-B等),去除其他影响后,每个不匹配基因,在移植后两年这个时间点,会导致约10%的累计失败...
到ＨＬＡ相合的亲缘供者。随着ＨＬＡ配型技术研究的进步和大型国际供者登记处的建立，非亲缘异基因骨髓移植（ＵＲＤ．ＢＭＴ）开展日益增多。成为造血干细胞移植重要的干细胞来源之一。非亲缘异基因骨髓移植和亲缘异基因骨髓移植相比，其并发症多，移植相关死亡率高，尤其是严重的移植物抗宿主病（ＧＶＨＤ）和植入...
A clinician′s guide to HLA matching in allogeneic hematopoietic stem cell transplant[J]. Hum Immunol, 2022,83(10):687-694. DOI: 10.1016/j.humimm.2022.03.002 . 返回引文位置Google Scholar 百度学术 万方数据 [4] Standards for accredited laboratories american society for histocompatibility and ...
Evaluation of HLA matching in unrelated hematopoietic stem cell transplantation for nonmalignant disorders. Blood 120 (14), 2918-2924.Horan J, Wang T, Haagenson M, Spellman SR, Dehn J, Eapen M, et al. Evaluation of HLA matching in unrelated hematopoietic stem cell transplantation for non- ...
Stem cell transplants for patients with X-linked agammaglobulinemia[J]. Clin Immunol, 2003, 107(2): 98-102. [5] 万鼎铭 , 刘长凤 , 王桂菊 , 等 . HLA 不全相合非血缘脐血移 植治疗无丙种球蛋白血症一例报告 [J]. 中华血液学杂志 , 2005, 26(7): 401-403. [6] Abu-Arja RF, ...
Allogeneic hematopoietic stem cell transplantation has demonstrated efficacy for numerous inherited metabolic disorders (IMDs). Umbilical cord blood transplant (UCBT) is increasingly used as a graft source in IMDs, but little is known of the impact of cord blood unit (CBU)/recipient HLA allelic disp...
用于HLA分型的方法、组合物和试剂盒.pdf,本发明涉及一组寡核苷酸和包含一组寡核苷酸的试剂盒,其中所述寡核苷酸用于测定DNA样品的HLA基因型。本发明还涉及一种测定DNA样品的HLA基因型的方法。该方法可以用于识别移植的合适供体和/或受体,以进行亲子测试;用于识别HLA类型,
Matching classical HLA alleles between donor and recipient is an important factor in avoiding adverse immunological effects in HSCT. Siblings with no differences in HLA alleles, either due to identical-by-state or identical-by-descent status, are conside
Class II human leukocyte antigens (HLA) play an important role in determining donor-recipient compatibility in solid organ and stem cell transplantation. Class II mismatching elicits strong alloimmune responses that impair transplant success. Preformed donor-specific anti-class II antibodies increase the...
Haemo- poietic stem/progenitor cell transplant in Fanconi anaemia using HLA-matched sibling umbilical cord blood cells. Br J Haematol 1993;85:419-422.Kohli-Kumar, M., Shahidi, N.T., Broxmeyer, H.E., Masterson, M., Delaat, C., Sambrano, J., Morris, C., Auerbach, A.D. & Harris...