图9. HLA LOH和TMB(E),TNB(F),CIN(G)和PD-L1表达(H)之间的关联 图10. HLA LOH协同TMB(D/E)和PD-L1(F/G)对ICI治疗的预测 除了在免疫治疗指导之外,HLA LOH也被证明是肿瘤进化的早期事件,例如,伦敦大学癌症研究所2017年发表在Cel...
图10. HLA LOH协同TMB(D/E)和PD-L1(F/G)对ICI治疗的预测 除了在免疫治疗指导之外,HLA LOH也被证明是肿瘤进化的早期事件,例如,伦敦大学癌症研究所2017年发表在Cell上的研究证实[11],约40%的早期非小细胞肺癌患者会发生HLA LOH,而在TRACERx数据队列中发现这种比例可能更高,并且HLA LOH会在发生在不同的NSCLC病...
图10. HLA LOH协同TMB(D/E)和PD-L1(F/G)对ICI治疗的预测 除了在免疫治疗指导之外,HLA LOH也被证明是肿瘤进化的早期事件,例如,伦敦大学癌症研究所2017年发表在Cell上的研究证实[11],约40%的早期非小细胞肺癌患者会发生HLA LOH,而在TRACERx数据队列中发现这种比例可能更高,并且HLA LOH会在发生在不同的NSCLC病...
HLA多态性对移植物抗宿主病的影响 造血干细胞移植供受者间HLA错配会触发T细胞和NK细胞的同种识别,诱导移植物抗宿主病(GVHD)、GVL效应,并有可能导致移植失败。国内数据显示,中度和重度急性GVHD发生率约为13%～47%,而发生率的差异主要与危险因素不同有关。在无关供...
HLA-E expression was detected in patient-derived tumor tissues with immunohistochemistry. HLA-E gene alleles in tumor tissues were detected with the polymerase chain reaction-sequence-specific primer method. In colorectal cancer tissue and in the normal tissue adjacent to the tumor, the HLA-E ...
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We thank all subjects for participating to this study. We acknowledge our collaborating clinical partners, all colleagues who contributed to patient recruitment, and our laboratory technicians and colleagues responsible for database management (for a complete list of all individuals, see theSupplementary ...
Osteosarcoma patient survival has remained stagnant for 30 years. Novel therapeutic approaches are needed to improve outcomes. We examined the expression of Programmed Death Ligand 1 (PD-L1) and defined the tumor immune microenvironment ... P Koirala,ME Roth,J Gill,... - 《Sci Rep》 被引量:...
mFuk expression alone suppressed tumor growth and increased total itICs comparably to oral l-fuc administration alone. Again, CD4+ and CD8+ T cells were the most increased itICs (Extended Data Fig. 1l,m and Fig. 1e–h). These data indicate that melanoma-specific fucosylation is an ...
HLA-DR expression was decreased on each subtype of monocyte of NHL patients, among which the difference of intermediate monocyte (CD14 ++CD16 +) (25.43 MFI vs. 33.52 MFI, P<0.01) and non-classical monocyte (CD14 +CD16 ++) (11.40 MFI vs. 15.70 MFI, P< 0.01) were of statistical ...