Intriguingly, a subset of genotypes was observed to have significant but opposite impact on HHV infection versus disease phenotypes (Fig.1D). A compound genotype encoding KIR2DS4 and its ligand A*11:02 is observed to be associated with reduced EBV/IgA/VCA seroconversion, a risk factor for NPC...
There is no doubt that this specificity is confined to DR molecules, but it is not clear whether this complex specificity, defined by the cytotoxicity reaction and representing probably several associated and cross-reactive determinants, is localized either on the DRB1 or the DRB3 gene product, ...
Conclusion. A common cluster of shared amino acids, or a shared epitope, identified within HLA - DRB1 among anti - U1 - 70-kd autoantibody positive connect... H Kaneoka,Kou〤hing Hsu,Y Takeda,... - 《Arthritis & Rheumatology》 被引量: 43发表: 2010年 加载更多研究...
61 RA patients with at least one HLA-DRB1 SE allele were considered to be SE-positive RA (SE + RA). Among the SE + RA group, 44 patients (72%) had at least one HLA-DRB1 04:05 allele, 14 patients (23%) had at least one 01:01 allele, and 6 patients (10%...
It has been suggested that three of the above-mentioned amino acid positions within HLA-DRB1 (11/13, 71, 74) and in two non-DRB-1 HLA (position 9 of HLA-B, position 9 of HLA-DPB1) account for the majority of HLA-associated genetic susceptibility to RA [133]. HLA-DRB1 haplotypes ...
(HLA-DR1toHLA-DR17). TheHLA-DRB3locus encodes theHLA-DR52specificity, is moderately variable and is variably associated with certain HLA-DRB1 types. TheHLA-DRB4locus encodes theHLA-DR53specificity, has some variation, and is associated with certain HLA-DRB1 types. TheHLA-DRB5locus encodes...
HLA-DRB1*11andHLA-DRB1*13also to be significantly decreased in pemphigus patients, but with a very broad 95% CI. In contrast to the Yan study39, there was no positive association withHLA-DRB1*08and pemphigus, but analysis of pemphigus vulgaris studies only (data not shown) could reproduce ...
HLA-DRB1*01 and HLA-DRB1*04 may be involved in the geneticsRF+ JIA. • HLA-DRB1*11 was confirmed to be predisposing to oligo-articular JIA. • HLA-DRB1*04 was confirmed to have a role insystemic JIA. • RF positivity seems to select JIA subset being immune-genetically similar to...
Graves' disease (GD) is a human leukocyte antigen (HLA) linked organ-specific autoimmune disease. In German GD patients the disease is associated with HLA specificities of the HLA-DRw52 family (HLA-DR3, -DR5, and DR6; HLA-DRB3 positive HLA haplotypes). Recently, a strong association with...
and HLA haplotypes DR3-DQB1*0201 and DR4-DQB1*0302 contribute to APS type III, the combination of AITD and T1D, frequently together with CeD. The haplotypes HLA- DRB1*03:01-DQA1*05:01-DQB1*02:01 and HLA-DRB1*04:01-DQA1*03:01-DQB1*03:02 were significantly overrepresented in APS ...