对某一个等位基因，先写出座位号，下接*号，再用4个数字代表这个等位基因的名字。比如你这个DRBl指HLA基因座位，*号后面的四位数中前两位是指这个等位基因相应的血清学特异性，如DRBl*0701中血清学特异性是DR4；后两位数则代表该等位基因序号。如果两个等位基因的4个数字不同，则这两个等位基因编码的...
Associations between HLA-DRB1*07:01 and lapatinib-induced hepatotoxicity have been reported. To consolidate the results from all available reports in scientific databases, systematic review and meta-analysis techniques were used to quantify these associations. Studies investigating associations between HLA-...
human leukocyte antigen (HLA) alleleHLA-DRB1*07:01:19sequence-based typingHLA-DRB1*07:01:19 differs from DRB1*07:01:01:01 by a single nucleotide substitution at position 261 of exon 2.Tissue AntigensM.-R. HuoB. XiY. YuD. Li
反复妊娠丢失(RPL)通常被定义为≥3次连续妊娠流产，这被认为是由母体对胎儿或滋养细胞的异常免疫反应引起的。人类白细胞抗原(HLA)-DRB1和-DQB1多态性与大多数自身免疫性疾病相关，因此对RPL患者HLA- DBB1多态性的研究具有实现意义。在之前的研究中，发现HLA-DRB1*03等位基因在RPL患者中具有更高的患病率。我们想要...
负相关:HLA-B*07:02、HLA-B*57:01 1型糖尿病(Type1diabetes,T1D) 正相关:HLA-DQA1*0301,HLA-DQA1*0501,HLA-DQB1*0201,HLA-DQB1*0302,HLA-DRB1*04,HLA-DRB1*0301,HLA-DRB1*0901; 负相关:HLA-DQA1*0103,HLA-DQA1*0201,HLA-DQA1*0401,HLA-DQB1*0301,HLA-DQB1*0402,HLA-DQB1*0501,HLA-DQB1*050...
After haplotype reconstruction the HLA-DRB1*07:01-HLA-DQB1*02:02 haplotype was associated with an increased risk. After inferring the HLA-DQA1 alleles the HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype was associated with the highest risk of asparaginase hypersensitivity (p=1.22x10...
综上所述,本研究未证实HLA-DRB1*03与RPL的关联,但首次检测到HLA-DRB1*07与RPL的关联。由于这种关联是一个新发现,它应该在未来的研究中得到证实。 01 前言 HLA基因位于染色体6p21.31的几个遗传位点上,它包含了人类已知的最多的多态性基因。...
Kawase等[2]分析了HLA错配组合对无关造血干细胞移植后III-IV级急性GVHD和总生存率的影响,发现了16种错配组合(HLA-A 4种,HLA-B 1种,HLA-C 7种,HLA-DRB1 1种,HLA-DRB1/DQB1 1种, HLA-DPB1 2种)均与严重急性GVHD显著有关(表2)。且一个和两个或两个...
正相关:HLA-B27、HLA-B*51:01、HLA-B*47:01、HLA-B*40:02、HLA-B*13:02、HLA-B*40:01; 负相关:HLA-B*07:02、HLA-B*57:01 1型糖尿病(Type1diabetes,T1D) 正相关:HLA-DQA1*0301,HLA-DQA1*0501,HLA-DQB1*0201,HLA-DQB1*0302,HLA-DRB1*04,HLA-DRB1*0301,HLA-DRB1*0901; ...
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