T cells. Class II is found in addition to class I on antigen-presenting immune cells such as dendritic cells, B-cells, monocytes, macrophages. There are 6 main class II genes (DPA1, DPB1, DQA1, DQB1, DRA, DRB1). MHC class II displays peptides derived from exogenous antigens such as...
蛋白别名: histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; MHC cell surface glycoprotein; MHC class II antigen DRA 基因别名: HLA-DRA; HLA-DRA1; MLRW UniProt ID: (Human) P01903 Entrez Gene ID: (Human) 3122 功能 MHC class I...
Function : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class ...
Methods: We adopted cross-species, single-cell RNA sequencing (scRNA-seq) analysis based on two published datasets containing circulating immune cell profile of septic patients as well as immune cell atlas of murine model of sepsis. Flow cytometry, laser scanning confocal microscopy (LSCM) imaging ...
除了DRA以外,所有其他链都是高度多态的(Robinson等,2003)。普通人群中HLA II类分子的广泛多态性确实代表了表位识别方法的巨大障碍。但是,已经认识到,通过关注最常表达的分子,可以将一般人群中表达的大多数分子协调为可管理的数量(McKinney等人,2013)。同时,在由不同等位基因变体结合的肽中甚至在不同基因座之间都存在...
‖类抗原在免疫应答中有着重要的作用,这一类抗原在体液免疫和细胞免疫反应中的调节作用是为辅助性T细胞(helperTcell,TH)提供外来抗原,使后者在识别外来抗原的同时识别 HLAⅡ类抗原而得以激活。如在免疫应答中,巨噬细胞的Ⅱ类抗原作为自身抗原与由巨噬细胞捕捉和处理后的外来抗原结合,激活TH细胞,TH细胞辅助B细胞分化...
CategoryB Cell Receptor Signaling; T Cell Receptor Signaling; Autophagy Signaling Background抗原呈递主要组织相容性复合体II类(MHCII)分子的β链。与α链HLA-DRA复合,在专职性抗原呈递细胞(APC)上展示抗原肽,以供HLA-DRB1限制性CD4阳性T细胞上的α-βT细胞受体(TCR)识别。
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 enc...
在研究设计方面,研究人员选用了具有 HLA 基因杂合等位基因的 YiP3 外周血单个核细胞(peripheral blood mononuclear cell,PBMC)来源的 iPS 细胞。他们针对 HLA-A、HLA-B 和 HLA-DRA 基因设计了引导 RNA(guide RNA,gRNA),并通过电穿孔的方法将 CRISPR-Cas9 试剂导入 iPS 细胞中,实现基因敲除。随后,进行单细胞克隆...
Symbol(s)HLA-DRA; HLA-DRA1 External IDsOMIM: 142860MGI: 95900Homologene: 7751 Gene Ontology Molecular Function:•MHC class II receptor activity Cellular Component:•lysosome •plasma membrane •integral to plasma membrane •membrane