基于GEO基质评分和免疫评分分析HLA-DRA在胃癌组织中的表达及其临床意义 ·1063·胃癌是世界范围内发病率和死亡率最高的恶 性肿瘤之一，其发病率和死亡率分别位居第五位和 第三位［1］。早期胃癌患者5年生存率可达90%以上，但由于胃癌起病隐匿、症状不典型，多数患者发现时已处于进展期［2］。了解胃癌的异质性，...
JeanLouis GuéantAntonino RomanoJoseAntonio CornejoGarciaAbderrahim OussalahCeline CheryNatalia BlancaLópezRosaMaria GuéantRodriguezFrancesco GaetaPierre RouyerThomas JosseElsevier Masson
Use of model organisms and in vitro techniques relevant to developmental biology and medicine are acceptable, as are translational human studies.doi:10.1203/00006450-199305001-00460Hanaki, KTamura, AErashima, HKohno, YOgihara, YTsuji, YTajima, KOkuda, HOhzeki, TShiraki, KPediatric Research...
The class II genes of the human Major Histocompatibility Complex (MHC) encode three isotypes of alpha/beta heterodimeric proteins, HLA-DR, -DQ, and -DP, which are responsible for presenting processed antigens to T helper lymphocytes. These MHC class II genes are expressed in a coordinate manne...
The cell surface HLA-DR molecule binds foreign peptide antigen and forms an intercellular complex with the T cell receptor in the course of the development of an immune response against or immune tolerance to the antigen represented by the bound peptide. The HLA-DR molecule also functions as a...
293T, HCT116 and HT-29 cells were co-transfected with a luciferase reporter that is driven by a fragment of the HLA-DRA promoter region (pDRA-luc) and an expression vector encoding either EGFP or an EGFP–AIM2 fusion protein. The activity of the empty vector pGL3-basic was used for ...
Since this SNP (rs7192, HLA00662.1:g.4276G>T p.Val217Leu) lies within exon 4, in the region encoding the cytoplasmic tail, the resulting protein is effectively monomorphic. For this reason, in‐depth studies on HLA‐DRA and its function have been limited. However, analysis of sequences ...
Since this SNP (rs7192, HLA00662.1:g.4276G>T p.Val217Leu) lies within exon 4, in the region encoding the cytoplasmic tail, the resulting protein is effectively monomorphic. For this reason, in‐depth studies on HLA‐DRA and its function have been limited. However, analysis of sequences ...
Feriotto G, Pozzi L, Ciucci A, Camarda G, Mischiati C, D'Agnano I, Gambari R & Giacomini P (1993) Methyla- tion state of the human HLA-DRA gene in T-lympho- cytes and B-lymphocytes of transgenic mice. Lack of methylation at one 5垄-GCGC site is not required for gene ...
The human HLA class II histocompatibility antigen, DR alpha chain ( HLA-DRA ) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence ...