由 DNA 测序定义的等位基因命名以识别基因,后跟星号、代表等位基因组的数字(通常对应于该等位基因编码的血清学抗原)、冒号和代表特定等位基因的数字(例如,A*02:01、DRB1*01:03、DQA1*01:02)。有时在冒号后添加额外的数字以识别编码相同蛋白质的等位基因变体,在另一个冒号后添加其他数字以表示内含子或 5' 或 3...
The HLA-DRB1 genetic loci may play the most important role in HLA-DQA1∗0102-DQB1∗0602-DRB1∗1501-DRB5∗0101 haplotype, which showed a strong association with MS [18]. HLA genes polymorphisms only make up 20–60% of the genetic predisposition to MS, which means a possible role ...
HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, -DQA1, -DQB1, -DPA1, and -DPB1 HLA-E, -G MICA,MICB,DRA KIRGene Content Typing onIlluminaplatform KIR3DL1,3DS1Gene Allele level typing onPacBioplatform FCGR(!) Gene NameVariant (SNP ID) ...
Specifically, human leukocyte antigens DQ2 and DQ8 (HLA-DQ2 and HLA-DQ8), respectively, composed of DQA1*05 and DQB1*02 monomers (DQ2), or DQA1*03 and DQB1*0302 (DQ8), are required for CeD [7]. Class II MHC receptors are expressed by professional APCs such as B cells, ...
aforementioned differentially expressed genes (DEGs). The results, presented in Fig.9A, B, revealed that within the sepsis group, there was a statistically significant upregulation of CTSO and HLA-DQA1 genes in comparison with the control group comprising healthy individuals (adjustedP-value < ...
呈负相关,表明Th1/Th2免疫失衡仍可能是哮喘发作的重要因素。3.存在与 不存在易感基因的哮喘患者血清IFN-γ、IL-4水平比较无显著差异,表明 HLA-DQA1*0301可能仅某种特应性变应原所致的哮喘有关,亦表明哮喘发 作与否不是由某个等位基因决定,其发作可能为多基因共同作用的结果。
HLA‐DQA1MHCMLCCR‐RFLPHLA allele typingWe modified a previously published PCR-RFLP for DQA1 typing (1) and examined the predictive value of HEA-DQA1 in mixed lymphocyte cultures (MLC) among matched (HLA generic types) pairs of unrelated individuals. There were 61/102 (60%) pairs with ...
人中有6个主要mhcii类基因:hla-dpa1、hla-dpb1、hla-dqa1、hla-dqb1、hla-dra和hla-drb1。mhcii类基因提供制备蛋白的说明,所述蛋白几乎完全在某些免疫系统细胞表面上。如同mhci类蛋白,这些蛋白将肽展示给免疫系统。生成自mhciii类基因的蛋白具有一些不同功能;其参与炎症和其他免疫系统活性。一些mhc基因的功能未知...
By analyzing 4340 public RNA-Seq datasets from 38 human tissues and 20 different hematopoietic cell populations, we generated a comprehensive expression atlas of classical (HLA-A, HLA-B, HLA-C) and non-classical (HLA-G,-E,-F) class I and class II (HLA-DPA1,-DPB1,-DQA1-DQB1,-DRA, ...
and HLA haplotypes DR3-DQB1*0201 and DR4-DQB1*0302 contribute to APS type III, the combination of AITD and T1D, frequently together with CeD. The haplotypes HLA- DRB1*03:01-DQA1*05:01-DQB1*02:01 and HLA-DRB1*04:01-DQA1*03:01-DQB1*03:02 were significantly overrepresented in APS ...