HLA‐DQA1*02:01:02new allelesequence‐based typingThe new allele, HLA-DQA1*02:01:02 differs from DQA1*02:01:01:01 by C to T substitution in exon 2.doi:10.1111/tan.13139Galluccio, TGuagnano, AStanglino, GVicenza, TAndreani, M....
doi:10.1111/tan.13139HLA-DQA1*02:01:02new allelesequence-based typingThe new allele, HLA-DQA1*02:01:02 differs from DQA1*02:01:01:01 by C to T substitution in exon 2.Tissue AntigensT.GalluccioA.GuagnanoG.StanglinoT.VicenzaM.Andreani...
HLA-DQA1 * 02∶01和HLA-DRB1 * 07∶01已被确定为拉帕替尼所致肝损伤的危险因素,用于预测接受拉帕替尼治疗的乳腺癌患者发生肝损伤的风险[34-35]。此外,新近一项大型药物遗传学研究[36]证实了HLA-B*57∶01与帕唑帕尼引起的转氨酶升高...
有趣的是,II类单倍型HLA- DRB1*15:01—DQA1*01:02—DQB1*06:02是AC- DILI的一个危险因子,它对I型DM和含有HLA- DQB1*06:02的单倍型具有保护作用,即使在携带HLA-DQA1*03:01的个体中也是如此。我们的数据支持DRB1*15:01—DQA1*01:02—DQB1*06:02单倍型...
负相关:HLA-B*07:02、HLA-B*57:01 1型糖尿病(Type1diabetes,T1D) 正相关:HLA-DQA1*0301,HLA-DQA1*0501,HLA-DQB1*0201,HLA-DQB1*0302,HLA-DRB1*04,HLA-DRB1*0301,HLA-DRB1*0901; 负相关:HLA-DQA1*0103,HLA-DQA1*0201,HLA-DQA1*0401,HLA-DQB1*0301,HLA-DQB1*0402,HLA-DQB1*0501,HLA-DQB1*050...
After inferring the HLA-DQA1 alleles the HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype was associated with the highest risk of asparaginase hypersensitivity (p=1.22x10 -5 ; OR=5.00 (2.43-10.29); n=257). Significantly fewer proportion of T-cell acute lymphoblastic leukemia ...
01产品方案 纳昂达HLA分型全流程解决方案参考 IPD-IMGT/HLA数据库设计,靶向11个HLA基因(I 类:HLA-A、B、C;II 类:HLA-DPA1、DPB1、DQA1、DAQB1、DRB1/3/4/5),通过多态性探针组合,覆盖全部等位基因的全长基因组序列,可支持第四数段高精度分型。
IPHASE/汇智和源凭借多年的研发经验,推出了多领域、多种类的高端科研试剂,为药物早期研发提供筛选工具,为生命科学领域的探索提供新材料、新方法和新手段,为遗传毒性研究提供便捷产品。此外,IPHASE/汇智和源可提供特殊产品的定制服务,望广大科研工作者来电咨询,咨询热线400-127-6686。
To test whether hcrt itself could be a possible target in the autoimmune attack, CD4+ T-cell reactivity towards six different 15-mer peptides from prepro-hypocretin with high predicted affinity to the DQA1*01:02/DQB1*06:02 MHC class II dimer was tested using EliSpot in a cohort of 22 ...
HLA-DQ8(DQA1*0301-DQB1*0302) 系统性红斑狼疮(Systemiclupuserythem-ato-sus,SLE) 正相关:HLA-DRB1*15:01、HLA-DQA1*01:02/04:01、HLA-DQA1*06:02、HLA-DQB1*06:08 负相关:HLA-DR*04、HLA-DQA1*05:01、HLA-DQA1*06:01、HLA-DQB1*03:02、HLA-DQB1*05:01 ...