Arnold ML, Pei R, Spriewald B, Wassmuth R. Anti-HLA class II antibodies in kidney re-transplant patients. Tissue Antigens. 2005; 65(4):370-378.Arnold ML, Pei R, Spriewald B, et al: Anti-HLA class II antibodies in kidney retransplant patients. Tissue Antigens 65:370, 2005...
AntibodiesImmunoglobulin IdiotypesCross ReactionsAmino Acid SequenceImmunoglobulin Heavy ChainsNo Abstract available for this article.doi:10.1038/306538a0Shaw, StephenMcMichael, AndrewNature Publishing Group UKNatureS. Shaw and A. McMichael, HLA class II antigens and monclonal antibodies, Nature 306: 538...
[1] O'Leary J G, Demetris A J, Friedman L S, et al. The role of donor-specific HLA alloantibodies in liver transplantation[J]. Am J Transplant,2014,14(4):779~787. [2] O'Leary J G, Kaneku H, Jennings...
in particular HLA class II antibodies are critical for the pathogenesis of AMR via interactions with endothelial cells (ECs). To investigate the effects of HLA class II antibody ligation to the graft endothelium
结果显示,26例(32%)的供者存在至少1个HLA II类抗原的抗体,接受这部分供者移植物的患者移植后急慢性GVHD的发生率显著高于供者HLA抗体阴性的患者(图3)。进一步分析发现,26名HLA抗体阳性供者中有13名(50%)存在针对患者HLA的特异性抗体(RSA)。供者源抗HLA抗体在移植后6...
Conclusion The effects of anti HLA- Ⅱ antibodies on renal allograft vary from different person, and protective antibodies may exist. 【Key words】 Kidney transplant ; Anti-HLA-II class antibody; Kidney function; Long-term survival ·25· 实用器官移植电子杂志 2016 年1 月第4 卷第1 期...
The class-II‒restricted TCCs expressed CD45RO, CD28, and the inhibitory receptors PD-1 and CTLA-4 (Supplementary Table S1); however, immune checkpoint blockade (anti‒PD-L1‒ and anti‒CTLA-4‒blocking antibodies) did not alter the strength of the induced proliferative response to ...
Werfen’s DonorScreen-HLA Class I and Class II assay offers a reliable, accurate and cost effective screening for HLA antibodies to help maintain your donor base. Our assay has been specifically designed to detect these antibodies in blood donors using the STRATEC BIOMEDICAL AG® GEMINI (GEMINI...
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 enc...
We have confirmed that 10F04mc TCR is class II HLA molecular restricted but can be expressed on the surface of both CD4+and CD8+human T cells (Fig.3a). When co-cultured with target cells, 10F04mc TCR-T cells secret cytokines and directly induce target cell lysis (Supplementary Movie1an...