HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomas. Br. J. Cancer, 59, 221.M.A. Lopez-Nevot, F. Esteban, A. Ferron, et al., HLA class I gene expression on ...
This class I molecules are polymorphic membrane glycoproteins composed of a heavy (alpha) chain (44 kDa) which is encoded by a HLA class I gene (HLA-A, B or C), and β2-microglobulin light (beta) chain (12 kDa). They are involved in the presentation of foreign antigens to the ...
Functional diversity of the highly polymorphic human leukocyte antigen class I (HLA-I) genes underlies successful immunologic control of both infectious disease and cancer. The divergent allele advantage hypothesis dictates that an HLA-I genotype with two alleles with sequences that are more divergent ...
(HLA-D). This class I molecules are polymorphic membrane glycoproteins composed of a heavy (alpha) chain (44 kDa) which is encoded by a HLA class I gene (HLA-A, B or C), and β2-microglobulin light (beta) chain (12 kDa). They are involved in the presentation of foreign antigens ...
Abstract: Class I regulatory complex (CRC) located in the 5′-upstream region of MHC class I. gene contains transcriptional enhancing sequences, called Enh A. This Enh A region contains tandem-arranged κB- like sites, one of which has a well-conserved perfect palindromic sequence. The second...
HLA class IPCRGenomic DNA of HLA class I gene segments was amplified by the polymerase chain reaction (PCR). The amplified 0.8 kb gene segment encompassed sequences corresponding to an exon 2 (伪1 domain), an intron 2 and an exon 3 (伪 2 domain). The PCR product was cloned in M13 ...
Johnson DR: Locus-Specific Constitutive and Cytokine- Induced HLA Class I Gene Expression J Immunol 2003, 170:1894-1902.Johnson, DR. (2003). Locus-... D Johnson - 《Journal of Immunology》 被引量: 0发表: 2003年 The regulation of HLA class I expression: is HLA-G the odd one out? Th...
HLA-C HLA-C是人类白细胞抗原（HLA）的一个基因座，位于6号染色体上。成熟的HLA-C蛋白会与β2微球蛋白组成异二聚体，作为一个受体锚定在细胞表面。相关介绍 HLA-C介绍
菱形代表 HLA I 类变体,三角形代表 HLA II 类变体,圆圈代表 HLA 基因内 SNP。大三角形代表 DRB1*0301 中的顶部信号。 Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk. Zhang C, Wiemels JL, Hansen HM, Gonzalez-Maya J, Endicott AA, de Smith AJ, Smirnov...