In contrast, if the molecular lesion is "reversible/soft", tumor cells can potentially recover HLA-class I expression and can finally be destroyed. These important new concepts are integrated together and gain a great importance in the new era of "immune checkpoint antibodies". Finally, the ...
Astrid HammerHeinz HutterGottfried DohrAmerican journal of reproductive immunology (New York, N.Y.: 1989)Hammer A., Hutter H., Dohr G. HLA class I expression on the materno-fetal interface. Am. J. Reprod. Immunol. 1997; 38 : 150–157....
[8] NEGRAO M V,LAM V K,REUBEN A,et al. PD-L1 Expression,tumor mutational burden,and cancer gene mutations are stronger predictors of benefit from immune checkpoint blockade than HLA class Ⅰ genotype in non-small cell lung cancer[J]. J Thorac Oncol,2019,14(6):1021-1031. DOI:10. 1016...
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Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigen types appear genetically regulated but not linked to major histocompatibility complex haplotype. J Exp Med,1996; 1 32、83: 1817-182712Uhrberg ...
Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma:a ra-tionale for T-cell-based ... Sundara,T Yayan,Kostine,... 被引量: 0发表: 0年 Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic ...
Hyperexpression of classical HLA class I (HLA-I) molecules in insulin-containing islets has become a widely accepted hallmark of type 1 diabetes pathology. In comparison, relatively little is known about the expression, function and role of non-classical subtypes of HLA-I. This review focuses on...
Class-Iexpressedonallnucleated cellsinman,andalsoonerythrocytes inmice. Class-IIexpressedprimarily on antigen presenting cells (dendritic cells, macrophages and B cells, etc.) Differential expression of MHC antigens 16 学习交流PPT Alloreactivity of T cells: MLR and CTL generation Alloreactivity of...
adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and ...
We report the case of a boy with low expression of HLA class I molecules on peripheral blood mononuclear cells, which is associated with immunodeficiency. The patient, who had a Marfan-like phenotype, had chronic deep skin ulcers and sinobronchiectasis. Immunohistologic examination of the ulcerated...