Examples have included SJS/TEN associated with carbamazepine (HLA-B*1502) and allopurinol (HLA-B*5801) and HLA-B*5701 with both abacavir hypersensitivity syndrome and flucloxacillin drug-induced liver disease. Despite this, several hurdles... S Mallal - 《World Congress of Basic & Clinical Pharma...
computational tools can still provide great insights. For example, the binding interactions of HLA-B*58:01 with allopurinol, HLA-A*31:01 and HLA-B*15:02 with carbamazepine, HLA-B*14:02 with nevirapine, HLA-DRB1*07:01 with ximelagatran, and HLA-B*53:01 with raltegravir have all been st...
HLA-B*58:01 associated with allopurinol-induced SCAR has been reported in both European and Asian populations, despite the latter being the main focus (Table 3). While this allele is also prevalent in African countries with frequency up to 8.2% (Zhou et al. Citation2021), no studies about...
et al. HLA-B*5701 screening for hypersensitivity to abacavir. N. Engl. J. Med. 358, 568–579 (2008). Article PubMed Google Scholar Hung, S. I. et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc. Natl Acad. Sci. USA ...
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Drug-induced liver injury (DILI) is an important cause of serious liver disease. The antimicrobial agent flucloxacillin is a common cause of DILI, but the ... - 《Nature Genetics》 被引量: 1273发...
HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008;358:568–79. Article Google Scholar Redwood AJ, Pavlos RK, White KD, Phillips EJ. HLAs: key regulators of T-cell-mediated drug hypersensitivity. HLA. 2018;91:3–16. Article CAS Google Scholar Illing PT, Vivian...
Johnson syndrome in response tocarbamazepine(a drug used to treat seizures). Another version, HLA-B*5801, is associated with an increased risk of severe skin reactions in people treated withallopurinol(a drug used to treat gout, which is a form of arthritis caused byuric acidin the joints)....
The present invention relates to a method for simultaneously detecting HLA-B*5801 allele and HLA-B*5701 allele which are for predicting adverse drug reactions of allopurinol and abacavir, and to a kit thereof and, more specifically, to a method and a kit for simultaneously detecting HLA-B*...
直接进行HLA‑B*58:01基因检测的方法相较于SNP连锁位点的更加准确、可靠。 [0014]目前可查的直接检测HLA‑B*58:01基因的专利多使用PCR‑SSP法(CN103805701A、CN103484533A、CN104017898)或多探针Taqman法(CN105950766B、CN109517891A、CN108624676A),但基于这些方法开发的试剂成本高,操作复杂,且检测的模板只能...
Allopurinol别嘌呤醇(治痛风)Gout(痛风病)SJS/TEN*HLA-B*5801 SJS:Steven-Johnson综合症TEN:毒性皮肤坏死(ToxicEpidermalNecrolysis)HLA-B*1502PrevalentinAsia TheriskofSJS/TENisestimatedtobeabout1to6per10,000newusersincountrieswithmainlyCaucasianpopulation.Theriskincreasesabout10timeshigheramongAsian...