examples include the strong association of Stevens鈥 Johnson syndrome and toxic epidermal necrosis (TEN) with HLA-B*1502, and treatment with the anti-convulsant drug carbamezepine in Han Chinese, Thais and Malays, and HLA-B*5801 with the use of allopurinol for the treatment of hyperuricemia....
et al. HLA-B*5701 screening for hypersensitivity to abacavir. N. Engl. J. Med. 358, 568–579 (2008). Article PubMed Google Scholar Hung, S. I. et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc. Natl Acad. Sci. USA ...
computational tools can still provide great insights. For example, the binding interactions of HLA-B*58:01 with allopurinol, HLA-A*31:01 and HLA-B*15:02 with carbamazepine, HLA-B*14:02 with nevirapine, HLA-DRB1*07:01 with ximelagatran, and HLA-B*53:01 with raltegravir have all been st...
computational tools can still provide great insights. For example, the binding interactions of HLA-B*58:01 with allopurinol, HLA-A*31:01 and HLA-B*15:02 with carbamazepine, HLA-B*14:02 with nevirapine, HLA-DRB1*07:01 with ximelagatran, and HLA-B*53:01 with raltegravir have all been st...
Johnson syndrome in response tocarbamazepine(a drug used to treat seizures). Another version, HLA-B*5801, is associated with an increased risk of severe skin reactions in people treated withallopurinol(a drug used to treat gout, which is a form of arthritis caused byuric acidin the joints)....
特异性位点和引物设计区域 的确定,它们主要位于HLA - B等位基因第2和第3外显子,然后根据特异性位点附近的区 域,结合等位基因阻滞突变系统(ARMS)的方法,设计TaqMan - MGB探针检测的特异性引物 以及探针,值得注意的是探针和引物设计的位置能够排除其它HLA - B等位基因的结合、识另Ij,尤其是HLA - B*570101等位...
Allopurinol别嘌呤醇(治痛风)Gout(痛风病)SJS/TEN*HLA-B*5801 SJS:Steven-Johnson综合症TEN:毒性皮肤坏死(ToxicEpidermalNecrolysis)HLA-B*1502PrevalentinAsia TheriskofSJS/TENisestimatedtobeabout1to6per10,000newusersincountrieswithmainlyCaucasianpopulation.Theriskincreasesabout10timeshigheramongAsian...
HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008;358:568–79. Article Google Scholar Redwood AJ, Pavlos RK, White KD, Phillips EJ. HLAs: key regulators of T-cell-mediated drug hypersensitivity. HLA. 2018;91:3–16. Article CAS Google Scholar Illing PT, Vivian...
直接进行HLA‑B*58:01基因检测的方法相较于SNP连锁位点的更加准确、可靠。 [0014]目前可查的直接检测HLA‑B*58:01基因的专利多使用PCR‑SSP法(CN103805701A、CN103484533A、CN104017898)或多探针Taqman法(CN105950766B、CN109517891A、CN108624676A),但基于这些方法开发的试剂成本高,操作复杂,且检测的模板只能...
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Drug-induced liver injury (DILI) is an important cause of serious liver disease. The antimicrobial agent flucloxacillin is a common cause of DILI, but the ... - 《Nature Genetics》 被引量: 1273发...