HLA-B*5801 : a genetic susceptibility to allopurinol-induced DRESS[J]. Med J Aust, 2016, 204(4): 159-160.Mugwagwa AN, Fischer R, Zailan I. HLA-B*5801: a genetic susceptibility to allopurinol-induced DRESS. Med J Aust 2016;204:159-60. http://dx.doi.org/10.5694/mja15.01113...
最近的研究表明,HLA-B * 5801等位基因是别嘌呤醇诱导的皮肤不良药物反应(cADR)的非常强的标志物。在本文中,我们报告了2例在携带HLA-B * 5801等位基因的患者中由别嘌呤醇引起的药疹,并根据MEDLINE和PubMed搜索回顾了有关HLA-B * 5801与别嘌呤醇诱导的cADR之间的关联的文献 著录项 来源 《Indian journal of...
Consider screening for HLA-B*5801 before starting treatment with allopurinol tablets in patients from populations in which the prevalence of this HLA-B*5801 allele is known to be high. Screening is generally not recommended in patients from populations in which the prevalence of HLA-B*58:01 is ...
Presence of the HLA-B*5801 allelic variant is strongly associated with severe allopurinol-induced hypersensitivity reactions, particularly in certain Asian populations. (See Pharmacogenomics of Allopurinol-induced Hypersensitivity Reactions under Cautions.) However, other genetic or nongenetic factors (e.g.,...
Consider screening for HLA-B*5801 before starting treatment with allopurinol tablets in patients from populations in which the prevalence of this HLA-B*5801 allele is known to be high. Screening is generally not recommended in patients from populations in which the prevalence of HLA-B*58:01 is...
Saokaew S, Tassaneeyakul W, Maenthaisong R, Chaiyakunapruk N. Cost-effectiveness analysis of HLA-B*5801 testing in preventing allopurinol-induced SJS/TEN in Thai population. PLoS One 2014;9:e94294.Saokaew, S., Tassaneeyakul, W., Maenthaisong, R., and Chaiyakunapruk, N. (2014). ...
The sensitivity and specificity of the HLA-B*5801 allele for prediction of allopurinol-induced SJS/TEN were 100 and 87%, respectively. By assuming a 0.2% prevalence rate, the positive predictive value and the negative predictive value of the HLA-B*5801 allele was 1.52 and 100%, respectively....
Genetic Testing (HLA B5801) prior to use if Hans Chinese, Thai or if CKD 3, Korean Stop Allopurinol if this occurs Increased risk when concurrent use ofBendamustine,Thiazide Diuretics,AmpicillinorAmoxicillin Toxic Hepatitis Gastrointestinal (Nausea,Diarrhea) ...
Analysis o价罪金情氢直争谈船刻降f allopuri存永电慢浓苗担风耐nol medication and hla-b* 5801 genotyp飞界接干歌乙乎秋ing of patients with drug eruption. 别嘌呤醇用药调查及其药疹患者hla-b*5801基因型分析。3.Allopurinol is a drug used in uric acid and calcium stone removal. 别嘌醇是一种...
2.Analysis of a来自llopurinol medication and hla-b* 5801 genotyping 因风of patients w360问答ith drug eruption. 别嘌呤醇用药调查及其药疹患者hla-b*5801基因型分析。3.Allopurinol is a drug used in uric acid and calcium stone removal. 别嘌醇是一种药物使用的尿酸和钙结石清除。