Allopurinol: Mechanism of Action & Structure Allopurinol: Pharmacokinetics & Pharmacodynamics Next Lesson Allopurinol: Contraindications, Food & Drug Interactions Allopurinol Nursing Considerations, Implications
2.1 Classification of the substance or mixture Acute toxicity - Oral, Category 3 Skin sensitization, Category 1 2.2 GHS label elements, including precautionary statements Pictogram(s) Signal word Danger Hazard statement(s) H301 Toxic if swallowed H317 May cause an allergic skin reaction Prec...
toxicity classificationhighly toxic acute toxicityoral-rat LD > 500 mg/kg; Oral-mouse LD50: 78 mg/kg flammability hazard characteristicscombustible, the fire field discharges nitrogen-containing oxides and pungent smoke storage and transportation characteristicswarehouse is low temperature, ventilated and dr...
A possible common mechanism of both drugs, i.e. disruption of purine synthesis, was discussed. We report on the outcome of 31 prospectively ascertained pregnancies with allopurinol exposure at least during first trimester. Pregnancy outcomes were 2 spontaneous abortions, 2 elective terminations of ...
Concerning the putative mechanism of action, allopurinol is an inhibitor of the enzyme xanthine oxidase, the final step in purine metabolism, converting hypoxanthine and xanthine into uric acid 1, 2, 3, 4, 5. Accumulation of hypoxanthine and xanthine may favor the action of the enzyme ...
Incident stroke was our study outcome of interest, defined as the first occurence of stroke during the study period after the initiation of a new allopurinol prescription. Incident stroke was identified by the presence of International Classification of Diseases, ninth revision, common modification (ICD...
For this analysis, we examined patients who had a diagnosis of both gout and diabetes. Gout was defined as the occurrence of an inpatient admission or 2 outpatient visits with a physician encounter at least 7 days apart and the presence of International Classification of Diseases, ninth revision...
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