HLA-B27 AntigenSelection (Genetics)AllelesHLA-B27抗原选择(遗传学)等位基因The existence of a small, discrete group of HLA-B27 promoters, potentially able to mitigate the deleterious effect of this allele, has not been confirmed.doi:10.1111/j.1744-313X.2007.00717.xB Müller...
et al. Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis. Ann. Rheum. Dis. 65, 775–780 (2006). CAS PubMed Google Scholar Brown, M. A., Kenna, T. & Wordsworth, B. P. Genetics of ankylosing spondylitis — insights into ...
Keywords:HLA-B27antigen/genetics; Polymerasechainreaction 人类白细胞抗原(humanleucocyteantigen, HLA)之特异性与多种临床疾病相关,如HLA-B27 基因与强直性脊柱炎和反应性关节炎具有很强的相关性[1],因此HLA-B27检测可用于腰痛和关节炎的鉴别诊断中。本文通过建立HLA-B27序列特异引物聚合酶链反应(sequencespecific...
2Genetics HLA-B27is aMHC class Iallele that forms the strongestgenetic risk factorforaxSpA. MHC class 1 molecules are expressed on thesurfaceof nucleate cells and can present peptides to CD8+T cells. HLA-B27 is present in 85–90% of the patients withASHLA-B27, and between 75 and 90% ...
Ankylosing spondylitis and reactive arthritis to HLA-B27HLA-B27 强直性脊柱炎和反应性关节炎 Multiple sclerosis to HLA-DR2HLA-DR2 多发性硬化症 Narcolepsy to HLA-DR2 and HLA–DQB1*06:02发作性睡病 HLA-DR2 和 HLA-DQB1*06:02 Psoriasis to HLA-C*06:02银屑病到 HLA-C*06:02 Rheumatoid arthri...
Hundreds of versions (alleles) of HLA-B are known, each of which is given a particular number (such as HLA-B27). Closely related alleles are categorized together; for example, at least 28 very similar alleles are subtypes of HLA-B27. These subtypes are designated as HLA-B*2701 to HLA-...
Khan M. Genetics of HLA-B27. Br J Rheumatol. 1988;27 Suppl 2:6–11. Article PubMed Google Scholar Khan M. A worldwide overview: the epidemiology of HLA-B27 and associated spondyloarthritides. In: Calin A, Taurog JD, editors. The spondyloarthritides. Oxford: Oxford University Press; 19...
One hundred and twenty-eight of 145 patients with ankylosing spondylitis (AS) were found to be HLA B27 positive. Five patients had evidence of a sero-negat... JC Woodrow,CJ Eastmond - 《Annals of the Rheumatic Diseases》 被引量: 74发表: 1978年 Genetics of HLA-B27. The various subtypes ...
需要用于减轻hla-b27阳性受试者中的自身免疫性炎症疾病的一种或多种症状的有效疗法。 技术实现要素: 本公开内容提供了通过施用编码hsp90或其活性片段的核酸,用于治疗hla-b27相关的自身免疫性炎性病症的方法和组合物。 相应地,本公开内容提供了用于治疗或预防hla-b27阳性受试者中的自身免疫性炎性疾病的方法,所述方...
geneticsHLA-B27polymorphismsspondyloarthropathiessubtypesHLA-B27 is the major genetic susceptibility factor for ankylosing spondylitis (AS). However, its precise role in the pathogenesis of AS still remains unclear, even though its gene has been cloned and sequenced, and its crystallographic structure ...