基于该研究结果,2022年1月,tebentafusp获批用于HLA-A*02:01阳性不可切除或转移性葡萄膜黑色素瘤,成为首个获批用于治疗晚期葡萄膜黑色素瘤的药物,打破了葡萄膜黑色素瘤的治疗困境。 图: IMCgp100-202研究里程碑事件(来源: 医药魔方DeepMed数据库) PD-L1<1%的不可切除或转移性黑色素瘤 黑色素瘤发病率约21.5/...
与CAR T疗法不同,选择TCR T疗法的患者必须不仅要表达目标抗原,而且还要表达相应的抗原限制的HLA等位基因。因此,TCR T疗法通常使用相对常见的HLA等位基因,如HLA-A*02:01。 · CARs和TCRs的受体亲和力基于抗体片段构成的CARs与抗原的亲和力通常在纳摩尔范围内。相比之下,天然TCRs其亲和力要小几个数量级,通常是在微...
The T-cell mediated innate immune response is defined by the interaction between antigen presenting cells and T cells, through the Major Histocompatibility Complex (MHC) and the T cell receptor (TCR). MHC molecules present a peptide to antigen-specific T cells that recognize this peptide. S...
Cell Culture The B-lymphoblastoid cell line JY (HLA-A∗02:01, HLA-B∗07:02, HLA-C∗07:02, HLA-DPA1∗01:03, HLA-DPB1∗02:01/04:02, HLA-DQA1∗01:03/03:01, HLA-DQB1∗03:02/06:03, HLA-DRA∗01, HLA-DRB1∗04:04/13:01, HLA-DRB4∗04, HLA-DRB5∗02) wa...
A catalog of HLA type, HLA expression, and neo- epitope candidates in human cancer cell lines Sebastian Boegel ab , Martin Löwer a , Thomas Bukur ab , Ugur Sahin abc & John C Castle a a TRON gGmbH - Translational Oncology at Johannes Gutenberg-University Medical Center gGmbH; ...
www.nature.com/scientificreports OPEN The Associations of HLA-A*02:01 and DRB1*11:01 with Hepatitis C Virus Spontaneous Clearance received: 05 March 2016 Are Independent of IL28B in theaccepted:20July2016 Chinese PopulationPublished:11August2016 Jieting Huang1,2,*, Ke Huang1,2,*, Ru...
Immunization of transgenic HLA-A*02:01/HLA-DRB1*01:01 mice with four of these double binding peptides gave rise to both HLA class I and class II restricted responses by CD8 and CD4 T cells, respectively, whereas four of the double binding peptides did result in HLA-A*02:01 restricted ...
Human cell line or patient-derived cellular RNA was collected from a variety of sources and in accordance with the University of Wisconsin and Dana Farber Cancer Research Center’s policy on human research subjects. Samples were anonymized prior to typing, and no genotyping results were released to...
Next, we reasoned that if a finite number of shared TCR specificities exist in a particular disease context, the number of specificity groups should reach saturation given enough patients. By bootstrapping from patients who carry at least one copy of the most prevalent HLA-A∗02:01 allele, ...
Subsequently, to develop a clinically relevant protocol for iPSCs generation, and to illustrate the applicability of the concept of HLA-based banking for cell therapy purposes, the first HLA-based iPS cell line in Saudi Arabia was generated. Clinically relevant methods were employed to generate the...