The T-cell mediated innate immune response is defined by the interaction between antigen presenting cells and T cells, through the Major Histocompatibility Complex (MHC) and the T cell receptor (TCR). MHC molec
Cell Culture The B-lymphoblastoid cell line JY (HLA-A∗02:01, HLA-B∗07:02, HLA-C∗07:02, HLA-DPA1∗01:03, HLA-DPB1∗02:01/04:02, HLA-DQA1∗01:03/03:01, HLA-DQB1∗03:02/06:03, HLA-DRA∗01, HLA-DRB1∗04:04/13:01, HLA-DRB4∗04, HLA-DRB5∗02) wa...
Empty CellHLA-A*02:01·peptide (Protein Data Bank code) G9L (5ENW)G11N (5F7D)G9V (5FA3)G13E (5EOT)Y9L (5F9J)Y10L (5FDW)Y16R (5FA4) Data collection Resolution range (Å)a 50.0–1.85 (1.89–1.85) 50.0–2.30 (2.38–2.3) 51.6–1.86 (1.89–1.85) 40–2.10 (2.18–2.1...
www.nature.com/scientificreports OPEN The Associations of HLA-A*02:01 and DRB1*11:01 with Hepatitis C Virus Spontaneous Clearance received: 05 March 2016 Are Independent of IL28B in theaccepted:20July2016 Chinese PopulationPublished:11August2016 Jieting Huang1,2,*, Ke Huang1,2,*, Ru...
The effect of intact APM apart from tapasin deficiency was studied using the tapasin-deficient 721.220-HLA-A*02:01 cell line. On these cells we were able to increase the stability of surface- expressed HLA-A*02:01 molecules but only for one out of the three exogenously added peptides (...
HLA编码基因是人类基因组中多态性最强的。迄今为止,已经有超过20,000个HLA-I类等位基因被确认。与CAR T疗法不同,选择TCR T疗法的患者必须不仅要表达目标抗原,而且还要表达相应的抗原限制的HLA等位基因。因此,TCR T疗法通常使用相对常见的HLA等位基因,如HLA-A*02:01。
Sometimes additional numbers are added after a colon to identify allelic variants that encode identical proteins, and after another colon, other numbers are added to denote polymorphisms in introns or in 5' or 3' untranslated regions (eg, A*02:101:01:02, DRB1*03:01:01:02).由 HLA 系统中...
Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial Article Open access Published: 09 April 2025 (2025) Cite this article Download PDF You have full access to this open access article
HLAscan virtually set allele *02:01:01 as a representative allele and discarded the four 8- digit alleles from the candidate list. Second, it is possible for all of the sequencing reads that map to one allele to consti- tute a subset of sequence reads that map to another allele. In ...
In breast, HLA-A*03:01, HLA-B*15:01 and HLA-C*07:02 had the lowest expression across the three genes, whereas HLA-A*24:02, HLA-B*08:01 and HLA-C*04:01 had the highest. HLA alternative splicing in normal tissue samples Given the role that HLA alternative splicing could have in...