图3. HLAtyping Panel双平台捕获结果 04 Illumina平台HLA分型表现 我们首先使用 HLA-HD、Athlates 和 OptiType 对 HLA 的 I 型和 II 型共计 12 个标准品分析,具体结果见表 3。HLA-HD 和 Athlates 比 OptiType 的 HLA I 型分型更加准确,两者仅在 A 基因的 24 个 allele 上错误分型 1 个位点,而 OptiT...
第三代DNA测序技术检测用时更短、检测结果精度更高,4 h即可实现HLA高分辨率分型,并可精确至第3区域(High resolution-3 field HLA Typing,HR-3F),具有广阔的临床应用前景[13]。 相较血清学分型,HLA高分辨率分型可反映出不同HLA分子...
nanoporecancerphaseimmunityhla-typingpacbio-datalocal-assemblylohhaplotypereads-binninghla-sequenceloss-of-heterozygositygenotype-frequencyallelic-imbalancehuman-leukocyte-antigens UpdatedMar 28, 2025 C++ Kourami: Graph-guided assembly for HLA alleles
参考文献 [1] Duke JL,Lind C,Mackiewicz K,et al. Determining performance characteristics of an NGS-based HLA typing method for clinical applications[J]. HLA,2016,87(3),141-152. [2] Wang C,Krishnakumar S,Wilhelmy J,et al. High-throughput, high-fidelity HLA genotyping with deep sequencing...
Typing for these polymorphisms is routinely done for transplantation.HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry. 仅用于科研。不用于诊断...
Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performanc...
However, the increase of alleles that are being described suggests that SSO methods might not be enough even for HLA-typing at antigen level because new ambiguities are continually being found. Some of the ambiguities involve alleles that were described at low frequencies and need to be resolved ...
别名:HLA-DRB1 antibody, DRB1 antibody, DRw10 antibody, FLJ75017 antibody, FLJ76359 antibody, HLA-DR1B antibody, HLA-DRB antibody, HLA-DRB1* antibody, SS1 antibody, HLA class II histocompatibility antigen, DRB1-1 beta chain antibody, MHC class II antigen DRB1*1 ...
Using CD8+ T cells from the blood and CSF as well as by micromanipulation of CD8+ T cells in CNS tissue sections, these groups applied complementarity-determining region (CDR) 3 spectratyping. This enabled them to determine the sequence of the β chain of the TCR, which confers the ...
antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone ...