have shown significant clinical anti-tumour efficacy and survival benefit[5]. However, some patients failed to benefit from the standard therapy and suffered from recurrence or progression of the disease. Thers is still an urgent clinical need to further expand the benefit population with advanced l...
The frequencies of A1 and of A5 are high regardless of the duration of disease.doi:10.1016/S0140-6736(71)91272-4Falk, JudyOsoba, DavidElsevier Ltd.LancetFalk, J. A. & Osaba, D. ( 1971 ) HL–A antigens and survival in Hodgkin's disease . Lancet ii , 1118 ....
Additionally, the patients were retrospectively divided according to risk factors (abnormal erythrocyte sedimentation rate (ESR), bulky mediastinal disease, > 3 involved nodes and extranodal involvement) into low [stage I/II; five patients (9%)], intermediate [stage III with adverse prognostic ...
Each of these studies showed that progression-free survival or overall survival rates were significantly higher with BV among patients with PET2-negative or PET2-positive disease. In the ACCRU-LY study (NCT02758717) of BV with nivolumab (Opdivo) as a frontline treatment for patients with HL, ...
To test general applicability of DeepHL, we compared the behavioral patterns of normal and Parkinson’s disease (PD) mice freely moving in an open field (Fig.4a). Although the primary cause of PD is considered to be the loss of dopaminergic inputs to the striatum, the type of motor sympt...
To further evaluate UCHL1 as a potential prognostic factor in NB, we reanalyzed three independent patient datasets (Oberthuer, Versteeg and Seeger) to examine the correlation between the mRNA expression of UCHL1 and the survival rate in NB. In the Oberthuer dataset, patients with high UCHL1...
(RECIST) v1.1, include an overall response rate (ORR) of 35.8%, median progression free survival (PFS) of 4.2 months, and disease control rate (DCR) of 72.6%. Subgroup analysis showed that in...
Levels IB Points to Understand Water SL and HL Water molecules are polar and hydrogen bonds form between them. Hydrogen bonding and dipolarity explain the cohesive, adhesive, thermal and solvent properties of water. Substances can be hydrophilic or hydrophobic ...
Signal-related Kinase; MTD: Maximum Tolerated Dose; ORR: Objective Response Rate; PD: Progressive Disease; PFS: Progression-Free Survival; PR: Partial Response; RECIST: Response Evaluation Criteria in Solid Tumors; RP2D: Recommended Phase II Dose; SD: Stable Disease; vaf: Variant allele frequency...
acute inflammatory disease model, while interleukin-17-pretreated MSCs exhibited enhanced therapeutic effects33. In the present study, untreated and DMSO-pretreated MSCs had poor therapeutic effects on ConA-induced liver injury, while LDN57444-pretreated MSCs notably alleviated this inflammatory disease. ...