Outcome in adult HLH is still poor, with malignancy-associated and HLH after alloSCT showing the worst prognosis. Diagnostic vigilance and early treatment is a prerequisite for improving outcome of adult HLH. In particular, high ferritin values should raise suspicion of HLH. Disclosures Hochhaus:...
Conclusions The main differences reside in the better prognosis of the patients with MAS and the lesser proportion associated with severe illness (p<0.005). The presence of autoimmune disease seems to act as a trigger factor per se, and the infection does not appear to play an important role ...
The prognosis is excellent, with no re- ported death or recurrence of disease in our case series. Abbreviations HLH: Hemophagocytic lymphohistiocytosis; VL: Visceral leishmaniasis; CNS: Central nervous system; EBV: Epstein-Barr virus; CMV: Cytomegalovirus; RT-PCR: Real-time polymerase chain ...
et al.Genomic Classification and Prognosis in Acute Myeloid Leukemia.N Engl J Med. 2016, 374(23...
Hemophagocytic lymphohistiocytosis (HLH) used to have a dismal prognosis. We report the final results of HLH-94, the largest prospective diagnostic/therapeutic HLH study so far. The treatment includes immunosuppressive and cytotoxic therapy aiming at clinical remission, followed by HSCT in patients with...
HLH-2004 方案.pdf,Histiocyte Society HLH-2004 Hemophagocytic Lymphohistiocytosis Study Group Treatment Protocol of the Second International HLH Study 2004 Start of the Study: January 2004 Chairman: Jan-Inge Henter, M.D., Ph.D., Stockholm, Sweden HLH-2004
The familial disease was associated with a better prognosis than secondary HLH (p=0.04). Unlike the pediatric population, where reduced intensity conditioning (RIC) was associated with higher survival, in adult patients there was no difference between the conditioning types. The choice of donor: ...
Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults. We conducted a single-center retrospective study of 78 consecutive adults who had sIL-2r measured for ...