A. & Henderson, L. S. ( 1973 ) HLA antigens and aeute lymphocytie leukemia: the nature of the association. Tissue Antigens 3 , 470 – 476 .Rogentine GN, Trapani RJ, Yankee RA, Henderson ES. HL-A antigens and acute lymphocytic leukemia: the nature of the HL-A2 association. Tissue...
Several pieces of evidence suggest that CD38 may be a key driver of all-transretinoic acid (RA)-induced differentiation. In HL-60 acute myeloid leukaemia cells, a model for RA-induced differentiation, RA induces dramatic upregulation of CD38 mRNA and protein expression within 8 h13,14,15,16....
HL-60-neo cells were predo- minantly promyelocytes with large nucleoli with dis- persed nuclear chromatin and the nuclear: cyto- plasmic ratio, an indicator of differentiation, was relatively high (Figure 2B). HL-60-bis cells showed a heterogeneous pattern of population. The main populations...
险的白血病,在FAB分型中,属急性非淋巴细胞白血病(AcmeNonlymphocytic Leukemia,ANLL)中的M3亚型,发病率大约占到成人急性髓系白血病的10%。 这种白血病有严重的出血倾向,容易引起弥漫性血管内凝血(diffuseintravascular coagulation,DIC)等严重的并发症,尤其在化疗时容易发生,这常导致患者早 ...
Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides A recombinant anti-CD25 immunotoxin, LMB-2, has shown clinical efficacy in and . Its activity in (B-CLL) is inferior but might be improved if B-CLL cells e...
In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia 2006, Blood Show abstract Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T...
4 DiscussionAcute promyelocytic leukemia (APL) accounts for about 8% to 15% of cases of acute nonlymphocytic leukemia, with an annual incidence of 2-3/million [5]. APL is char-acterized by specific chromosome translocation t (15; 17) (q22; q21) and results in a characteristic fusion ...
The mutant construct was verified by DNA sequencing and subcloned into the KpnI and NcoI site of a luciferase expressing pGVB2 vector. 2.2. Cell culture HL-60-C15, an eosinophil-committed subline of HL-60, a promyelocytic leukemia cell line, was a generous gift from S.A. Fischkoff [18]...
Lymphocytic leukemia P-388 tumor cells (1 transplanted intraperitoneally into each of five CDF.sub.1 male mice weighing about 22 grams. Twenty-four hours after transplantation, 0.2 ml of a PBS (phosphate-buffered saline) solution of DC 113 was intraperitoneally administered to each mouse. For com...
Increased Risk for Non-Hodgkin Lymphoma in Individuals With Celiac Disease and a Potential Familial Association We identified 37,869 NHL, 8323 Hodgkin lymphoma (HL), and 13,842 chronic lymphocytic leukemia patients diagnosed in Sweden between 1965 and 2004, as ... Y Gao,SY Kristinsson,LR Goldin...