这些发现阐明了通过有氧糖酵解介导的PD-L1表达上调的新机制,并且强调了HK2作为葡萄糖传感器和蛋白激酶在调控肿瘤免疫逃逸中的作用。 The tumor cell membrane protein programmed cell death ligand 1 (PD-L1, also known as B7-H1) specifically binds to programmed cell death 1 (PD-1) on T cells, thereby...
Immune therapies targeting the PD-1/PD-L1 pathway have been employed in the treatment of breast cancer, which requires aerobic glycolysis to sustain breast cancer cells growth. However, whether PD-L1 expression is regulated by glycolysis in breast cancer cells remains to be...
肿瘤细胞在有氧条件下也以无氧呼吸为主,称作Warburg效应。HK2是催化有氧呼吸第一阶段的关键酶,定位于线粒体外膜上,可将肿瘤细胞吸收的葡萄糖转化为6-磷酸葡萄糖(G-6-P),然而过量的G-6-P会促进HK2从线粒体外膜上脱落,通过消耗能量引起IκBα的磷酸化和降解,进而造成PD-L1的高表达,最终抑制了T细胞介导的肿瘤...
PKM2及PD-L1在前列腺癌组织中的表达及其临床意义 前列腺特异性抗原,淋巴结转移和Gleason评分)之间的关系.采用SPSS 26.0统计软件进行统计分析.[结果] PKM2和PD-L1在前列腺癌组织中的阳性表达率显著高于良性前列腺增生... 姜华,张贺,江松松 - 《肿瘤学杂志》 被引量: 0发表: 2024年 ...
Introduction: Nivolumab is a recombinant, humanized monoclonal antibody that binds PD-1. The binding of PD-1 with PD-L1, expressed on antigen-presenting ce... A Farolfi,G Schepisi,V Conteduca,... - 《Expert Opinion on Drug Metabolism & Toxicology》 被引量: 4发表: 2016年 A phase II tria...
HR24-A ABG6E BJ153-10080A2 LE-30 TA38-08X100-SUS TA60-20X100R BSTH8A 908-026-01 912-026-01 MBID16A BJ771-05001N BJ771-05001N ELH44 BJ651-06001 ETH3743-CL VIP100A ER28 CTR1535 HAST8-55 OC4 CLH-165FB GRL50-R-SUS GRL50BL-SUS QLPD150-5X5 KR16X30-SUS FKR6X20-SV KR...
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百欧恩泰是一家德国生物技术公司,最为知名的产品当属与辉瑞合作的mRNA新冠疫苗。其也在开发针对特定患者的治疗严重疾病的有效免疫疗法,该公司的mRNA癌症疫苗主要与罗氏合作,与PD-L1抗体联合治疗晚期癌症,目前处于二期临床阶段。 癌症疫苗被认为是作为继化疗、放疗、细胞和免疫治疗之后的新型肿瘤治疗方式,也是肿瘤领域近年...
该研究首次报道ABZ能显著增强小鼠抗肿瘤免疫并下调肿瘤PD-L1表达,并揭示了ABZ通过下调UBQLN4促进肿瘤PD-L1泛素化降解的分子机制。同时,该研究提出ABZ联合新型免疫检查点CD73抑制剂有效治疗黑素瘤与肺癌的新策略,并阐明UBQLN4/PD-L1是评估抗PD-1治疗疗效的有效预测分子。