Once HIV has gained the entry into the cell, the virus sheds its protein coat, releasing its genetic information of RNA strand along with the reverse tranase into the cytosol. Inside the cytosol, the virus can take advantage of the availability of substrates to reversely transcribe the RNA gen...
Sexual transmission has become the primary mode of HIV transmission. Over 95% of new HIV cases in recent years are transmitted through sexual contact, with about 3/4 being male. Male-to-male sexual behavior is the primary...
Now, in the 27 years since HIV was identified as the cause of AIDS,we've developed more drugs to treat HIV than all other viruses put together.These drugs aren't cures, but they represent a huge triumph of science because they take away the autom...
The USPSTF also found convincing evidence that identification and treatment of pregnant women living with HIV infection is of substantial benefit in reducing the rate of mother-to-child transmission. The USPSTF found adequate evidence that ART is associated with some harms, including neuropsychiatric, ...
inhibited the cytochrome P450 3A4 (CYP3A4) enzyme in the liver that degraded saquinavir. CYP3A4 is the most abundant CYP isozyme in the liver. Moreover, the availability of saquinavir marked the beginning of combination therapy as cocktail drugs by introducing protease inhibitors to the clinic....
In 2022, the country with the highest HIV rate in the world was Eswatini. At that time, all of the 10 countries with the highest rates of HIV were in Africa.
The characteristics of HIV-positive patients who were followed up in ICUs have also changed over the years. In this study, we aimed to evaluate the demographic data, laboratory findings, indication for admission, and mortality rate of HIV-positive patients ...
In Fiji, the infection rate of HIV has increased over the last 25 years from 0.7 per 100,000 to 7 per 100,000 population. According to the Ministry of Health, this may reflect better diagnosis and reporting of cases, but also reflect a real increase in the number of cases....
administration of disease prevention and control, currently, over 90 percent of people diagnosed with HIV in China are on antiretroviral therapy and over 95 percent of those on treatment have reached viral load suppression, enabling the overall national HIV/AIDS incidence rate to remain at a low ...
To adjust the long-term trends, we used models before treat-all to predict data after June 2016 without treat-all, which represents the counterfactual scenario. Incidence rate ratio (IRR) was calculated by comparing the fitted numbers from the model with the expected numbers from the ...