HIV/HCV antiviral drug interactions in the era of direct-acting antivirals. Rice DP Jr,Faragon JJ,Banks S,et al. J Clin Transl Hepatol . 2016Rice DP Jr, Faragon JJ, Banks S, Chirch LM. HIV/HCV antiviral drug interactions in the era of direct-acting antivirals. J Clin Transl Hepatol...
一种可能的原因是HIV和HCV合并感染者的HCV病毒载量明显高于单独的HCV感染者[41] [42] [43],且HIV/HCV合并感染者相较于单纯的HCV感染者进展到肝硬化的速度更快[44] [45] [46] [47],并且有可能在2-3年内出现显著的肝纤维化发展[48] [49] [50]。 用这名医护人员存储的血清在美国疾病控制与预防中心(C...
Prof. Jurgen Rockstroh:In the setting of HIV and hepatitis C, when you choose your HIV regimen and your HCV regimen, you have to be aware of drug-drug interactions. In particular, hepatitis C protease inhibitors interact with NNRTIs ...
相较于HBV或HCV单一感染,HIV合并HBV、HCV感染患者的肝纤维化进展更快,以肝硬化并发症、HCC、肝病相关死亡为代表的终末期肝病风险更高。尽管HIV/HCV合并感染患者经直接抗病毒药物(DAA)治疗后,肝脏相关终点事件及肝病相关死亡风险有所降低,但全因死亡、非肝脏...
服药依从性(adherence)不佳是导致ART失败的最主要原因,其他常见原因包括:传播性耐药(transmitted drug resistance)、药物-药物相互作用(drug-drug interactions)、药物-食物相互作用(drug-food interactions)。 在她首次出现HIV阳性反应的16个月后,另一个WB确证实验结果仍然显示不确定的条带。她改用替诺福韦(TDF)+奈韦...
9. Huhn G D, Ramgopal M, Jain M K, et al. HIV/HCV therapy with ledipasvir/sofosbuvir after randomized switch to emtricitabine-tenofovir alafenamide-based single-tablet regimens[J]. PloS one, 2020, 15(1): e0224875. 10. Liverpool HIV DDI Checker. https://www.hiv-druginteractions.org. ...
临床中要密切关注患者合并用药情况,并参考其他相关指南或药物说明书及时调整药物方案或调整药物剂量。由于相互作用的详细信息经常更新,临床医生可以在处方前登录利物浦大学关于肝炎药物相互作用的网页(https://www.hep-druginteractions.org),该网站包括与处方药和非处方药的相互作用。
Drug interactions between direct-acting anti-HCV antivirals sofosbuvir and ledipasvir and HIV antiretrovirals. Abstract: 15th International Workshop on Clinical Pharmacology of HIV & Hepatitis Therapy; 2014; Washington, DC. Naggie S, Cooper C, Saag M et al. Ledipasvir and sofosbuvir for HCV in ...
2 Medications for SUDs have few clinically significant drug-drug interactions with ART and HCV direct-acting antivirals2; therefore, medication treatments for SUDs should not be withheld for those receiving ART or direct-acting antivirals (evidence rating: AIa). Clinical guidelines recommend ...
[9]Huhn G D,Ramgopal M,Jain M K,et al.HIV/HCV therapy with ledipasvir/sofosbuvir after randomized switch to emtricitabine-tenofovir alafenamide-based single-tablet regimens[J].PloS one,2020,15(1):e0224875. [10]Liverpool HIV DDI Checker.https://www.hiv-druginteractions.org.Accessed May 2021...